ArticleAdvanced healthcare materials2018
Monolithic and Scalable Au Nanorod Substrates Improve PEDOT-Metal Adhesion and Stability in Neural Electrodes.
Article in Advanced healthcare materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Ion-shielding ultrathin encapsulation with hot-press bonded interface enables chronic stretchable bioelectronics.Science advances · 2026Article
- Customized ultra-flexible and adhesive spinal cord stimulation electrode for chronic pain management.Materials today. Bio · 2026Article
- Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Electropolymerization of Organic Mixed Ionic-Electronic Conductors: Fundamentals and Applications in Bioelectronics.Chemical reviews · 2026Review
- Bidirectional mechanisms and emerging strategies for implantable bioelectronic interfaces.Bioactive materials · 2025Review
- Soft Bioelectronic Interfaces for Continuous Peripheral Neural Signal Recording and Robust Cross-Subject Decoding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- High-Precision, Low-Threshold Neuromodulation With Ultraflexible Electrode Arrays for Brain-to-Brain Interfaces.Exploration (Beijing, China) · 2025Article
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- Long-Term Neural Recording Performance of PEDOT/CNT/Dexamethasone Coated Electrode Array Implanted in Visual Cortex of Rats.Advanced nanobiomed research · 2025Article
- Inkjet-printed transparent electrodes: Design, characterization, and initial in vivo evaluation for brain stimulation.PloS one · 2025Article
- Materials and devices for high-density, high-throughput micro-electrocorticography arrays.Fundamental research · 2025Review
- Surface-Grafted Biocompatible Polymer Conductors for Stable and Compliant Electrodes for Brain Interfaces.Advanced healthcare materials · 2024Article
- Bioelectronic Neural Interfaces: Improving Neuromodulation Through Organic Conductive Coatings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Intraoperative application and early experience with novel high-resolution, high-channel-count thin-film electrodes for human microelectrocorticography.Journal of neurosurgery · 2024Article
- A Comparative Study on the Effect of Substrate Structure on Electrochemical Performance and Stability of Electrodeposited Platinum and Iridium Oxide Coatings for Neural Electrodes.Micromachines · 2023Article
- Synthesis of PEDOT:PSS Brushes Grafted from Gold Using ATRP for Increased Electrochemical and Mechanical Stability.ACS macro letters · 2023Article
- Transparent Electronics for Wearable Electronics Application.Chemical reviews · 2023Review
- Recent Progress on Poly(3,4-Ethylenedioxythiophene):Poly(Styrenesulfonate) Bioelectrodes.Small science · 2023Article
- Advances in electrode interface materials and modification technologies for brain-computer interfaces.Biomaterials translational · 2023Review
- Constructing 2D maps of human spinal cord activity and isolating the functional midline with high-density microelectrode arrays.Science translational medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Poly(3,4-ethylenenedioxythiophene) or PEDOT is a promising candidate for next-generation neuronal electrode materials but its weak adhesion to underlying metallic conductors impedes its potential. An effective method of mechanically anchoring the PEDOT within an Au nanorod (Au-nr) structure is reported and it is demonstrated that it provides enhanced adhesion and overall PEDOT layer stability. Cyclic voltammetry (CV) stress is used to investigate adhesion and stability of spin-cast and electrodeposited PEDOT. The Au-nr adhesion layer permits 10 000 CV cycles of coated PEDOT film in phosphate buffered saline solution without delamination nor significant change of the electrochemical impedance, whereas PEDOT coating film on planar Au electrodes delaminates at or below 1000 cycles. Under CV stress, spin-cast PEDOT on planar Au delaminates, whereas electroplated PEDOT on planar Au encounters surface leaching/decomposition. After 5 weeks of accelerated aging tests at 60 °C, the electrodeposited PEDOT/Au-nr microelectrodes demonstrate a 92% channel survival compared to only 25% survival for spin-cast PEDOT on planar films. Furthermore, after a 10 week chronic implantation onto mouse barrel cortex, PEDOT/Au-nr microelectrodes do not exhibit delamination nor morphological changes, whereas the conventional PEDOT microelectrodes either partially or fully delaminate. Immunohistochemical evaluation demonstrates no or minimal response to the PEDOT implant.
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