ArticleSmall (Weinheim an der Bergstrasse, Germany)2018
Picoanalysis of Drugs in Biofluids with Quantitative Label-Free Surface-Enhanced Raman Spectroscopy.
Article in Small (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Background-Free, Label-Free, and Reproducible SERS via Plasma-Halide-Engineered Gold Nanoparticles.ACS measurement science au · 2026Article
- Discrimination of Closely RelatedBiology · 2026Article
- Gold- or Silver-Nanoparticle SERS Platforms for Plasma-Based Diagnostics and AI-Driven Analysis.Sensors (Basel, Switzerland) · 2026Review
- Rapid SERS assay for determination of the opioid fentanyl using silver-coated sharply branched gold nanostars.Mikrochimica acta · 2024Article
- Iodine-Modified Ag NPs for Highly Sensitive SERS Detection of Deltamethrin Residues on Surfaces.Molecules (Basel, Switzerland) · 2023Article
- A Rapid Therapeutic Drug Monitoring Strategy of Carbamazepine in Serum by Using Coffee-Ring Effect Assisted Surface-Enhanced Raman Spectroscopy.Molecules (Basel, Switzerland) · 2022Article
- Vibrational Spectroscopy in Urine Samples as a Medical Tool: Review and Overview on the Current State-of-the-Art.Diagnostics (Basel, Switzerland) · 2022Review
- Antibiotic Susceptibility Testing with Raman Biosensing.Antibiotics (Basel, Switzerland) · 2022Review
- Rapid Assay for the Therapeutic Drug Monitoring of Edoxaban.Biomolecules · 2022Article
- Part-Per-Billion Level Chemical Sensing with a Gold-Based SERS-Active Substrate.Sensors (Basel, Switzerland) · 2022Article
- Human metabolite detection by surface-enhanced Raman spectroscopy.Materials today. Bio · 2022Article
- Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids.Science advances · 2021Article
- Rapid Formation of Nanoclusters for Detection of Drugs in Urine Using Surface-Enhanced Raman Spectroscopy.Nanomaterials (Basel, Switzerland) · 2021Article
- Facile synthesis of silver/gold alloy nanoparticles for ultra-sensitive rhodamine B detection.RSC advances · 2021Article
- Silver nanoparticle on zinc oxide array for label-free detection of opioids through surface-enhanced raman spectroscopy.RSC advances · 2021Article
- Surface Enhanced Raman Spectroscopy for Quantitative Analysis: Results of a Large-Scale European Multi-Instrument Interlaboratory Study.Analytical chemistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The enormous increase of Raman signal in the vicinity of metal nanoparticles allows surface-enhanced Raman spectroscopy (SERS) to be employed for label-free detection of substances at extremely low concentrations. However, the ultimate potential of label-free SERS to identify pharmaceutical compounds at low concentrations, especially in relation to biofluid sensing, is far from being fully realized. Opioids are a particular challenge for rapid clinical identification because their molecular structural similarities prevent their differentiation with immunolabeling approaches. In this paper, a new method called quantitative label-free SERS (QLF-SERS) which involves the formation of halide-conjugated gold nanoclusters trapping the analyte of interest near the SERS hot spots is reported, and it is demonstrated that it yields a 10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.