Evidence map›Paper›PMID 30368904›Full record

ArticleMagnetic resonance in medicine2019

Accurate fatty acid composition estimation of adipose tissue in the abdomen based on bipolar multi-echo MRI.

Manuel Schneider, Gemini Janas, Felix Lugauer, Elisabeth Hoppe, Dominik Nickel, Brian M Dale, Berthold Kiefer, Andreas Maier, Mustafa R Bashir

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07178145 (MRI of Epicardial Adipose Tissue Composition), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07178145 phase4recruitingstarted 2025, after this paper: background citation

MRI of Epicardial Adipose Tissue Composition: Development of Methods and Application to Heart Failure With Preserved Ejection Fraction

Ran2025Enrolled192Registered outcomes6Posted comparisons0ConditionsEpicardial Adipose Tissue, Heart Failure Preserved Ejection FractionArmsGLP-1RA
Open the trial in the graph
3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  8. Free-breathing MRI techniques for fat and RMagma (New York, N.Y.) · 2024
    Review
  9. Trajectory correction enables free-running chemical shift encoded imaging for accurate cardiac proton-density fat fraction quantification at 3T.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024 · on this map
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manuel SchneiderPattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Gemini JanasRadiology, Duke University Medical Center, Durham, North Carolina.
Felix LugauerPattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Elisabeth HoppePattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Dominik NickelMR Applications Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany.
Brian M DaleMR R&D Collaborations, Siemens Healthineers, Cary, North Carolina.
Berthold KieferMR Applications Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany.
Andreas MaierPattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Mustafa R BashirRadiology, Duke University Medical Center, Durham, North Carolina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo develop a bipolar multi-echo MRI method for the accurate estimation of the adipose tissue fatty acid composition (FAC) using clinically relevant protocols at clinical field strength.

methodsThe proposed technique jointly estimates confounding factors (field map,

resultsEcho train readout durations of at least five times the conventional in-phase time were required for accurate FAC estimation in areas of high fat content. In vitro, linear regression and Bland-Altman analyses demonstrated strong (r > 0.94) and significant (P ≪ 0.01) correlations between measured and reference FACs for all acquisitions, with smaller overall intercepts and biases at 3T compared to 1.5T. In vivo, reported mean absolute differences between test and retest were 1.54%, 3.31%, and 2.63% for the saturated, mono-unsaturated, and poly-unsaturated fat component, respectively.

conclusionsAccurate and reproducible MRI-based FAC quantification within a breath-hold is possible at clinical field strengths.

Indexed as

Magnetic Resonance ImagingAbdomenAdipose TissueAdolescentAdultAlgorithmsArtifactsBreath HoldingChildChild, PreschoolFatty AcidsFemaleHumansImaging, Three-DimensionalLeast-Squares AnalysisMaleFatty AcidsTriglyceridesadipose tissue fatty acid quantificationbipolar multi-echo MRInonalcoholic fatty liver diseasenonalcoholic steatohepatitistriglyceride saturation estimation

Identifiers

PMID30368904

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.