Evidence map›Paper›PMID 30368893›Full record

ArticleMagnetic resonance in medicine2019

Dynamic diffusion-weighted hyperpolarized

Xucheng Zhu, Jeremy W Gordon, Robert A Bok, John Kurhanewicz, Peder E Z Larson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xucheng ZhuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Robert A BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
University of California System · USUniversity of California, San Francisco · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI MethodsR01EB017449 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2017
$5.9M
Novel Hyperpolarized MR Markers of Advanced Prostate Cancer TherapyR01CA166655 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2012 to 2016
$3.0M
New Instrumentation and Techniques for Hyperpolarized Metabolic and Perfusion MRIR01EB013427 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2016
$2.8M
Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and MetabolismR01EB016741 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL · 2014 to 2017
$2.0M
American Cancer Society #131715-RSG-18-005-01-CCENCI NIH HHS R01 CA166655NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB013427NIBIB NIH HHS R01 EB016741NIBIB NIH HHS R01 EB017449NIH HHS P41EB013598NIH HHS R01CA166655NIH HHS R01EB013427NIH HHS R01EB016741NIH HHS R01EB017449
6 · The paper itself

Abstract

purposeTo develop a pulse sequence to dynamically measure the ADC of hyperpolarized substrates during their perfusion, metabolic conversion, and transport.

methodsWe proposed a slice-selective double spin echo sequence for dynamic hyperpolarized

resultsThe optimized pulse sequence outperforms the traditional sequence with smaller saturation effects on the magnetization of hyperpolarized compounds that allowed more dynamic imaging frames covering a longer imaging time window. In pre-clinical studies (N = 8), the dynamic hyperpolarized lactate ADC maps of 6 studies in the prostate tumors showed an increase measured ADC over time, which might be related to lactate efflux from the tumor cells.

conclusionsThe proposed sequence was validated and shown to improve dynamic diffusion weighted imaging compared to the traditional double spin echo sequence, providing ADC maps of lactate through time.

Indexed as

AnimalsCarbon-13 Magnetic Resonance SpectroscopyComputer SimulationDiffusion Magnetic Resonance ImagingLactic AcidMaleMiceMice, TransgenicModels, TheoreticalPhantoms, ImagingProstatic NeoplasmsPyruvatesLactic AcidPyruvatesADC mappingdynamic imaginghyperpolarized 13Cmetabolic imaging

Identifiers

PMID30368893
PMCPMC6347546
OpenAlexW2898378935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.