ArticleClinical oral investigations2019
Effect of ionizing radiation after-therapy interval on bone: histomorphometric and biomechanical characteristics.
Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture.BioMed research international · 2022Pooled it
- Quantifying early pelvic radiation-induced bone injury with dual-energy CT: a rabbit model study of dynamic bone mineral and marrow adiposity changes.Frontiers in medicine · 2026Article
- Prevalence and Determinants of Impaired Bone Mineral Density and Fractures in the First National Dutch Wilms Tumor Survivor Cohort, a National DCCSS-LATER Study.Cancer medicine · 2025Article
- Evaluation of the effect of nano-hydroxyapatite/silica gel bone graft and/or hemodialysate paste on the regeneration and nano-mechanical properties of calvarial bone in gammairradiated albino rats.Oral and maxillofacial surgery · 2025Article
- Evaluation of radiation therapy on grafted and non-grafted defects: an experimental rat model.Journal of applied oral science : revista FOB · 2025Article
- Recent Advances in the Surgical Management of Radiation-Induced Fractures following Soft Tissue Sarcomas.Journal of clinical medicine · 2024Review
- Ionizing radiation effects on osseointegration: a pre-clinical study.Brazilian oral research · 2024Article
- Effects of different doses of ionizing radiation on alveolar bone repair in post-extraction tooth socket: an experimental study in rats.Clinical oral investigations · 2023Article
- Review of the Pathogenesis, Diagnosis, and Management of Osteoradionecrosis of the Femoral Head.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Therapy-induced bone changes in oncology imaging withAnnals of nuclear medicine · 2022Review
- Biomechanical Properties of Metastatically Involved Osteolytic Bone.Current osteoporosis reports · 2020Review
- Effects of ionizing radiation on woven bone: influence on the osteocyte lacunar network, collagen maturation, and microarchitecture.Clinical oral investigations · 2020Article
- Biomechanical and morphological changes produced by ionizing radiation on bone tissue surrounding dental implant.Journal of applied oral science : revista FOB · 2020Article
- Systemic osteoprotective effects ofChinese medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to evaluate the effects of radiotherapy on biomechanical, histomorphometric, and microstructural characteristics of bone, in diverse periods, compared with intact bone tissue. MATERIALS AND
methodsEighteen adult male New Zealand rabbits were treated with a single radiation dose of 30 Gy. The animals were randomly divided into six groups: NoIr, control group, no radiation, and five irradiated groups sacrificed after 24 h (Ir24h), 7 (Ir7d), 14 (Ir14d), 21 (Ir21d), and 28 (Ir28d) days. After these periods, the animals were sacrificed and their tibias (n = 6) evaluated using three-point bending test to calculate the ultimate force, work to failure, and bone stiffness. Dynamic indentation test was used to quantify Vickers hardness and elasticity modulus of bone tissue. Micro-CT was used to analyze the cortical volume (CtV), cortical thickness (CtTh), and porosity (Ct.Po). Histomorphometric assessment was based on the lacunarity of bone tissue. Data were analyzed using one-way ANOVA and Kruskal-Wallis tests followed by Tukey, Dunnet, and Dunn's post-tests (P < 0.05).
resultsThe ultimate force, work to failure, stiffness, elastic modulus, and Vickers hardness values of irradiated bone were significantly lower that non-irradiated bone. Irradiated bone showed significantly lower CtTh and CtV values and higher CtPo than non-irradiated bone. No significant difference was found for lacunarity between non-irradiated bone and irradiated bone.
conclusionsIonizing radiation decreases normal anisotropy on microarchitecture of cortical bone, and increases bone fragility compared with non-irradiated bone. Further, these changes were seen after longer periods (e.g., 14 and 21 days), and not immediately after radiation therapy. CLINICAL RELEVANCE: The radiotherapy reduces bone mechanical properties and the normal structure of organic and inorganic bone matrix. For studying the protocols to protect the radiotherapy effect using rabbit model, the use of the sacrificing period between 14 and 21 days is recommended.
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