ArticleRheumatology international2018
Validation of methods for converting the original Disease Activity Score (DAS) to the DAS28.
Article in Rheumatology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Integrated Multi-Level Investigation of Friend Leukemia Integration 1 Transcription Factor as a Novel Immune-Inflammatory Biomarker in Rheumatoid Arthritis: Bridging Bioinformatics, Clinical Cohorts, and Mechanistic Validation.Journal of inflammation research · 2025Article
- The role of comorbidities alongside patient and disease characteristics in long-term disease activity in RA using UK inception cohort data.Rheumatology (Oxford, England) · 2022Article
- Predictors of poor function in RA based on two prospective UK inception cohorts. Do comorbidities matter?Rheumatology (Oxford, England) · 2022Article
- Self-reported fatigue in patients with rheumatoid arthritis compared to patients with cancer: results from two large-scale studies.Rheumatology international · 2022Article
- Toward Overcoming Treatment Failure in Rheumatoid Arthritis.Frontiers in immunology · 2021Review
- Secular changes in the progression of clinical markers and patient-reported outcomes in early rheumatoid arthritis.Rheumatology (Oxford, England) · 2020Observational
- Analysis of the correlation between disease activity score 28 and its ultrasonographic equivalent in rheumatoid arthritis patients.European journal of rheumatology · 2020Article
- Remission vs low disease activity: function, quality of life and structural outcomes in the Early Rheumatoid Arthritis Study and Network.Rheumatology (Oxford, England) · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The Disease Activity Score (DAS) is integral in tailoring the clinical management of rheumatoid arthritis (RA) patients and is an important measure in clinical research. Different versions have been developed over the years to improve reliability and ease of use. Combining the original DAS and the newer DAS28 data in both contemporary and historical studies is important for both primary and secondary data analyses. As such, a methodologically robust means of converting the old DAS to the new DAS28 measure would be invaluable. Using data from The Early RA Study (ERAS), a sub-sample of patients with both DAS and DAS28 data were used to develop new regression imputation formulas using the total DAS score (univariate), and using the separate components of the DAS score (multivariate). DAS were transformed to DAS28 using an existing formula quoted in the literature, and the newly developed formulas. Bland and Altman plots were used to compare the transformed DAS with the recorded DAS28 to ascertain levels of agreement. The current transformation formula tended to overestimate the true DAS28 score, particularly at the higher end of the scale. A formula which uses all separate components of the DAS was found to estimate the scores with a higher level of precision. A new formula is proposed that can be used by other early RA cohorts to convert the original DAS to DAS28.
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