ArticleAlzheimer's research & therapy2018
Functional connectivity in cognitive control networks mitigates the impact of white matter lesions in the elderly.
Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.Alzheimer's research & therapy · 2026Article
- Modeling and evaluating longitudinal brain maintenance and cognitive reserve using episodic memory, brain structure, and functional connectivity in older adults.GeroScience · 2026Article
- Metabolism fluctuation coupling can track the progression of dementia and describe MST1 gene-related pathology.Communications medicine · 2026Article
- Do cognitive reserve proxies capture a common neural signature? A systematic review and meta-analysis of task-based fMRI studies.Psychoradiology · 2026Review
- Brain connectivity moderated the effects of cognitive intraindividual variability on mobility in cognitively frail older adults.Frontiers in aging neuroscience · 2025Article
- The structural-functional-connectivity coupling of the aging brain.GeroScience · 2024Article
- Educational Attainment Moderates Task-State Control Network Connectivity Relations to Response Conflict Among Healthy Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks.PloS one · 2024Article
- Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note.Journal of cardiovascular development and disease · 2023Article
- Connectivity between default mode and frontoparietal networks mediates the association between global amyloid-β and episodic memory.Human brain mapping · 2023Article
- Cognitive training based on functional near-infrared spectroscopy neurofeedback for the elderly with mild cognitive impairment: a preliminary study.Frontiers in aging neuroscience · 2023Article
- The Key Role of Magnetic Resonance Imaging in the Detection of Neurodegenerative Diseases-Associated Biomarkers: A Review.Molecular neurobiology · 2022Review
- Earlier Alzheimer's disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading.Nature communications · 2022Article
- Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline.Scientific reports · 2022Article
- Association between Changes in White Matter Microstructure and Cognitive Impairment in White Matter Lesions.Brain sciences · 2022Article
- Estimated Regional White Matter Hyperintensity Burden, Resting State Functional Connectivity, and Cognitive Functions in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults.Frontiers in psychology · 2022Article
- Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults.Frontiers in integrative neuroscience · 2022Article
- Neuroplasticity of Glioma Patients: Brain Structure and Topological Network.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCerebrovascular pathology, quantified by white matter lesions (WML), is known to affect cognition in aging, and is associated with an increased risk of dementia. The present study aimed to investigate whether higher functional connectivity in cognitive control networks mitigates the detrimental effect of WML on cognition.
methodsNondemented older participants (≥ 50 years; n = 230) underwent cognitive evaluation, fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and resting state functional magnetic resonance imaging (fMRI). Total WML volumes were quantified algorithmically. Functional connectivity was assessed in preselected higher-order resting state networks, namely the fronto-parietal, the salience, and the default mode network, using global and local measures. Latent moderated structural equations modeling examined direct and interactive relationships between WML volumes, functional connectivity, and cognition.
resultsLarger WML volumes were associated with worse cognition, having a greater impact on executive functions (β = -0.37, p < 0.01) than on memory (β = -0.22, p < 0.01). Higher global functional connectivity in the fronto-parietal network and higher local connectivity between the salience network and medial frontal cortex significantly mitigated the impact of WML on executive functions, (unstandardized coefficients: b = 2.39, p = 0.01; b = 3.92, p = 0.01) but not on memory (b = -5.01, p = 0.51, b = 2.01, p = 0.07, respectively). No such effects were detected for the default mode network.
conclusionHigher functional connectivity in fronto-parietal and salience networks may protect against detrimental effects of WML on executive functions, the cognitive domain that was predominantly affected by cerebrovascular pathology. These results highlight the crucial role of cognitive control networks as a neural substrate of cognitive reserve in older individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.