Evidence map›Paper›PMID 30368078›Full record

ArticleiScience2018

Photo-Enhanced Singlet Oxygen Generation of Prussian Blue-Based Nanocatalyst for Augmented Photodynamic Therapy.

Dongdong Wang, Ruohong Shi, Jiajia Zhou, Sixiang Shi, Huihui Wu, Pengping Xu, Hui Wang, Guoliang Xia, Todd E Barnhart, Weibo Cai and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Tissue Factor-Targeted "OFrontiers in oncology · 2020
    Article
  9. Review
  10. Fighting Hypoxia to Improve PDT.Pharmaceuticals (Basel, Switzerland) · 2019
    Review
  11. Targeted Delivery of Chlorin e6Frontiers in pharmacology · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Dongdong WangHefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
Ruohong ShiHefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
Jiajia ZhouAnhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
Sixiang ShiDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.
Huihui WuAnhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
Pengping XuHefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
Hui WangThe Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China. Electronic address: hw39@hmfl.ac.cn.
Guoliang XiaHefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
Todd E BarnhartDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: wcai@uwhealth.org.
Zhen GuoAnhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230026, PR China. Electronic address: zhenguo@ustc.edu.cn.
Qianwang ChenHefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China; The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China. Electronic address: cqw@ustc.edu.cn.
University of Science and Technology of China · CNUniversity of Wisconsin–Madison · USChinese Academy of Sciences · CN

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP) NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy.

Indexed as

Biological SciencesCatalysisChemistryDrug Delivery SystemInorganic Chemistry

Identifiers

PMID30368078
PMCPMC6203243
OpenAlexW2897323207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.