Evidence map›Paper›PMID 30367952›Full record

Trial reportNeuroImage2019

Targeting reduced neural oscillations in patients with schizophrenia by transcranial alternating current stimulation.

Sangtae Ahn, Juliann M Mellin, Sankaraleengam Alagapan, Morgan L Alexander, John H Gilmore, L Fredrik Jarskog, Flavio Fröhlich

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05159336 (Intervention Treatment of Auditory Hallucination by Transcranial Alternating Current Stimulation), which is not on this map. Cited by 80 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05159336 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Intervention Treatment of Auditory Hallucination by Transcranial Alternating Current Stimulation

TypeinterventionalSponsorShanghai Mental Health CenterRan2021 to 2023Enrolled30ConditionsSchizophreniaArmstACS for auditory hallucinations via single arm
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sangtae AhnDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.
Juliann M MellinDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.
Sankaraleengam AlagapanDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.
Morgan L AlexanderDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.
John H GilmoreDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.
L Fredrik JarskogDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; North Carolina Psychiatric Research Center, Raleigh, NC, 27610, United States.
Flavio FröhlichDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States. Electronic address: flavio_frohlich@med.unc.edu.

Funding

Rational Optimization of tACS for Targeting Thalamo-Cortical OscillationsR01MH111889 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2016 to 2019
$2.4M
Targeting Cortical Dynamics: Rational Design of Individualized Brain StimulationR01MH101547 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2013 to 2017
$2.2M
Targeting Auditory Hallucinations with Alternating Current StimulationR33MH105574 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO, JARSKOG, LARS FREDRIK · 2017 to 2019
$816k
Targeting Auditory Hallucinations with Alternating Current StimulationR21MH105574 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO, JARSKOG, LARS FREDRIK · 2015 to 2016
$478k
NIMH NIH HHS R01 MH101547NIMH NIH HHS R01 MH111889NIMH NIH HHS R21 MH105574NIMH NIH HHS R33 MH105574
6 · The paper itself

Abstract

Transcranial alternating current stimulation (tACS) modulates endogenous neural oscillations in healthy human participants by the application of a low-amplitude electrical current with a periodic stimulation waveform. Yet, it is unclear if tACS can modulate and restore neural oscillations that are reduced in patients with psychiatric illnesses such as schizophrenia. Here, we asked if tACS modulates network oscillations in schizophrenia. We performed a randomized, double-blind, sham-controlled clinical trial to contrast tACS with transcranial direct current stimulation (tDCS) and sham stimulation in 22 schizophrenia patients with auditory hallucinations. We used high-density electroencephalography to investigate if a five-day, twice-daily 10Hz-tACS protocol enhances alpha oscillations and modulates network dynamics that are reduced in schizophrenia. We found that 10Hz-tACS enhanced alpha oscillations and modulated functional connectivity in the alpha frequency band. In addition, 10Hz-tACS enhanced the 40Hz auditory steady-state response (ASSR), which is reduced in patients with schizophrenia. Importantly, clinical improvement of auditory hallucinations correlated with enhancement of alpha oscillations and the 40Hz-ASSR. Together, our findings suggest that tACS has potential as a network-level approach to modulate reduced neural oscillations related to clinical symptoms in patients with schizophrenia.

Indexed as

AdultAlpha RhythmAuditory PerceptionCerebral CortexConnectomeDouble-Blind MethodElectroencephalographyHallucinationsHumansPlacebosSchizophreniaTranscranial Direct Current StimulationPlacebosAlpha oscillationAuditory hallucinationAuditory steady-state responseElectroencephalographyFunctional connectivitySchizophrenia

Identifiers

PMID30367952
PMCPMC6338501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.