Evidence map›Paper›PMID 30367888›Full record

ReviewJournal of neuroscience methods2019

High resolution approaches for the identification of amyloid fragments in brain.

J A Ross, P M Mathews, E J Van Bockstaele

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuroscience methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

J A RossDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, Philadelphia, PA 19102, United States. Electronic address: jar485@drexel.edu.
P M MathewsDepartment of Psychiatry, New York University Langone Medical Center, New York University, New York, and the Nathan Kline Institute, Orangeburg, NY, United States.
E J Van BockstaeleDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, Philadelphia, PA 19102, United States.
Drexel University · USNathan Kline Institute for Psychiatric Research · US

Funding

Uncovering Alzheimer's disease risk mechanisms through neuron-specific analysis of autophagy and endosomal-lysosomal functionP01AG017617 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI NIXON, RALPH A. · 2000 to 2021
$40.0M
OPIOID MODULATION OF THE COERULEO-CORTICAL PATHWAYR01DA009082 · NIDA · THOMAS JEFFERSON UNIVERSITY · PI VAN BOCKSTAELE, ELISABETH J · 2001 to 2017
$6.0M
Modulation of norepinephrine by cannabinoidsR01DA020129 · NIDA · THOMAS JEFFERSON UNIVERSITY · PI VAN BOCKSTAELE, ELISABETH J · 2005 to 2017
$3.5M
Neuronal Protective Apolipoprotein E2-mediated endocytic and exocytic pathwaysRF1AG057517 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEVY, EFRAT, MATHEWS, PAUL M · 2017 to 2020
$2.4M
Norepinephrine: A Novel Regulator of Amyloid Beta-42 PeptidesR21AG058263 · NIA · DREXEL UNIVERSITY · PI THOMAS, STEVEN A, VAN BOCKSTAELE, ELISABETH J · 2018 to 2019
$458k
NIA NIH HHS P01 AG017617NIA NIH HHS R21 AG058263NIA NIH HHS RF1 AG057517NIDA NIH HHS R01 DA009082NIDA NIH HHS R01 DA020129
6 · The paper itself

Abstract

backgroundIt is now widely recognized that endogenous, picomolar concentrations of the 42 amino acid long peptide, amyloid-β (Aβ

resultsNovel antibodies and a detailed protocol for immunoelectron microscopy using acrolein as a fixative are described. Acrolein is shown to preserve intraneuronal Aβ

conclusionsUsing novel and highly specific antibodies in combination with electron microscopy may reveal important information about the timing of aberrant protein accumulation, as well as the progression of abnormalities in the endolysosomal systems that sort and clear these peptides.

Indexed as

Brain ChemistryAmyloid beta-PeptidesAnimalsAntibodiesBrainMicroscopy, ElectronNeuronsPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)AntibodiesPeptide FragmentsAmyloidAntibodiesElectron microscopy

Identifiers

PMID30367888
PMCPMC6451891
OpenAlexW2898486608

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.