ArticleInternational journal for parasitology2018
The Plasmodium LAP complex affects crystalloid biogenesis and oocyst cell division.
Article in International journal for parasitology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Targeting protein-protein interactions in Plasmodium: from asexual replication to sexual development.Parasites & vectors · 2026Review
- A pleckstrin homology domain protein is involved in crystalloid formation inFrontiers in cellular and infection microbiology · 2026Article
- The molecular mechanisms driving Plasmodium cell division.Biochemical Society transactions · 2024Review
- The Multiple Roles of LCCL Domain-Containing Proteins for Malaria Parasite Transmission.Microorganisms · 2024Review
- Plasmodium sporozoite excystation involves local breakdown of the oocyst capsule.Scientific reports · 2023Article
- Identification of genes required for Plasmodium gametocyte-to-sporozoite development in the mosquito vector.Cell host & microbe · 2023Article
- Streamlining sporozoite isolation from mosquitoes by leveraging the dynamics of migration to the salivary glands.Malaria journal · 2022Article
- Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum.Nature communications · 2021Article
- Using scRNA-seq to Identify Transcriptional Variation in the Malaria Parasite Ookinete Stage.Frontiers in cellular and infection microbiology · 2021Article
- Plasmodium berghei LAPs form an extended protein complex that facilitates crystalloid targeting and biogenesis.Journal of proteomics · 2020Article
- NAD(P) transhydrogenase has vital non-mitochondrial functions in malaria parasite transmission.EMBO reports · 2020Article
- Dysregulated gene expression in oocysts of Plasmodium berghei LAP mutants.Molecular and biochemical parasitology · 2019Article
- Who Needs a Contractile Actomyosin Ring? The Plethora of Alternative Ways to Divide a Protozoan Parasite.Frontiers in cellular and infection microbiology · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Malaria parasite oocysts located on the mosquito midgut generate sporozoites by a process called sporogony. Plasmodium berghei parasites express six LCCL lectin domain adhesive-like proteins (LAPs), which operate as a complex and share a localisation in the crystalloid - an organelle found in the ookinete and young oocyst. Depletion of LAPs prevents crystalloid formation, increases oocyst growth, and blocks sporogony. Here, we describe a LAP4 mutant that has abnormal crystalloid biogenesis and produces oocysts that display reduced growth and premature sporogony. These findings provide evidence for a role of the LAP complex in regulating oocyst cell division via the crystalloid.
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