Evidence map›Paper›PMID 30367816›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019

Biocompatibility of common implantable sensor materials in a tumor xenograft model.

Mark E Gray, James Meehan, Ewen O Blair, Carol Ward, Simon P Langdon, Linda R Morrison, Jamie R K Marland, Andreas Tsiamis, Ian H Kunkler, Alan Murray and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. [Biomedical applications of bionic untethered micro-nano robots].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021
    Review
  5. Review
  6. In vivo validation of a miniaturized electrochemical oxygen sensor for measuring intestinal oxygen tension.American journal of physiology. Gastrointestinal and liver physiology · 2019
    Article
  7. Biocompatibility of common implantable sensor materials in a tumor xenograft model.Journal of biomedical materials research. Part B, Applied biomaterials · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Mark E GrayThe Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, EH25 9RG, UK.
James MeehanCancer Research UK Edinburgh Centre and Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Ewen O BlairSchool of Engineering, Faraday Building, Edinburgh, EH9 3JL, UK.
Carol WardThe Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, EH25 9RG, UK.
Simon P LangdonCancer Research UK Edinburgh Centre and Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Linda R MorrisonThe Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, EH25 9RG, UK.
Jamie R K MarlandSchool of Engineering, Faraday Building, Edinburgh, EH9 3JL, UK.
Andreas TsiamisSchool of Engineering, Faraday Building, Edinburgh, EH9 3JL, UK.
Ian H KunklerCancer Research UK Edinburgh Centre and Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Alan MurraySchool of Engineering, Faraday Building, Edinburgh, EH9 3JL, UK.
David ArgyleThe Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, EH25 9RG, UK.
University of Edinburgh · GBRoslin Institute · GBEdinburgh Cancer Research · GBHeriot-Watt University Malaysia · MY

Funding

UK Engineering and Physical Sciences Research Council EP/K-34510/1
6 · The paper itself

Abstract

Real-time monitoring of tumor microenvironment parameters using an implanted biosensor could provide valuable information on the dynamic nature of a tumor's biology and its response to treatment. However, following implantation biosensors may lose functionality due to biofouling caused by the foreign body response (FBR). This study developed a novel tumor xenograft model to evaluate the potential of six biomaterials (silicon dioxide, silicon nitride, Parylene-C, Nafion, biocompatible EPOTEK epoxy resin, and platinum) to trigger a FBR when implanted into a solid tumor. Biomaterials were chosen based on their use in the construction of a novel biosensor, designed to measure spatial and temporal changes in intra-tumoral O

Indexed as

Prostheses and ImplantsAnimalsBiocompatible MaterialsBiosensing TechniquesCell Line, TumorCollagenEpoxy ResinsFemaleFluorocarbon PolymersForeign-Body ReactionHumansMiceNeoplasms, ExperimentalPlatinumPolymersSilicon CompoundsBiocompatible MaterialsCollagenEpoxy ResinsFluorocarbon Polymersparyleneperfluorosulfonic acidPlatinumPolymersSilicon CompoundsSilicon Dioxidesilicon nitrideSmart MaterialsXylenesbiocompatibilityforeign body responseimplantable biosensorinnate immune responsetumor microenvironmenttumor xenograft model

Identifiers

PMID30367816
PMCPMC6767110
OpenAlexW2898228629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.