ArticleHuman brain mapping2019
Hippocampal subfields alterations in adolescents with post-traumatic stress disorder.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02510755 (Stress and Emotional Memory), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stress and Emotional Memory : Functional Neuroanatomy of Post-traumatic Stress Disorder in Adolescents
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- A meta-analysis of the relation between hippocampal volume and memory ability in typically developing children and adolescents.Hippocampus · 2022Pooled it
- Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- Trial
- The ventral/anterior hippocampus as a central hub for stress-related dopaminergic circuit dysfunction in psychiatric disorders.Molecular psychiatry · 2026Review
- A circuit from the basolateral amygdala to hippocampal CA3 regulates social behavior.Current biology : CB · 2025Article
- Associations Between Experience of Typical Variations in Stressors and Hippocampal Structure and Functional Connectivity in Childhood.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females.Scientific reports · 2025Article
- Scene construction deficits in adolescent PTSD are in sensory, rather than spatial, imagery.Frontiers in psychology · 2025Article
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
- Advances in Repetitive Transcranial Magnetic Stimulation for the Treatment of Post-traumatic Stress Disorder.Alpha psychiatry · 2024Review
- Narration of a collective traumatic event according to the presence of PTSD and considering the social function.Frontiers in psychiatry · 2024Article
- Development and validation of a quality control procedure for automatic segmentation of hippocampal subfields.Hippocampus · 2023Article
- Post-traumatic Stress Disorder: Focus on Neuroinflammation.Molecular neurobiology · 2023Review
- Neural correlates of disaster-related prenatal maternal stress in young adults from Project Ice Storm: Focus on amygdala, hippocampus, and prefrontal cortex.Frontiers in human neuroscience · 2023Article
- Cross-sectional field study comparing hippocampal subfields in patients with post-traumatic stress disorder, major depressive disorder, post-traumatic stress disorder with comorbid major depressive disorder, and adjustment disorder using routine clinical data.Frontiers in psychology · 2023Article
- Musical experience prior to traumatic exposure as a resilience factor: a conceptual analysis.Frontiers in psychology · 2023Review
- The DRD2 Taq1A polymorphism moderates the effect of PTSD symptom severity on the left hippocampal CA3 volume: a pilot study.Psychopharmacology · 2022Article
- Volumetric differences in hippocampal subfields and associations with clinical measures in myalgic encephalomyelitis/chronic fatigue syndrome.Journal of neuroscience research · 2022Article
- Variations in response to trauma and hippocampal subfield changes.Neurobiology of stress · 2021Article
- Stability of hippocampal subfield volumes after trauma and relationship to development of PTSD symptoms.NeuroImage · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Reexperiencing symptoms in adolescent Post-Traumatic Stress Disorder (PTSD) are characterized by the apparition of vivid intrusive images of the traumatic event. The emergence of these intrusions is thought to be related to a deficiency in context processing and could then be related to hippocampal alterations. The hippocampus is a complex structure which can be divided into several subfields, namely, the Cornu Ammonis (CA1, CA2, and CA3), the subiculum, and the dentate gyrus (DG). As each subfield presents different histological characteristics and functions, it appears more relevant to consider hippocampal subfields, instead of only assessing the whole hippocampus, to understand the neurobiology of PTSD. Hence, this study presents the first investigation of structural alterations within hippocampal subfields and their links to reexperiencing symptoms in adolescent PTSD. Hippocampal subfields were manually delineated on high-resolution MRI images in 15 adolescents (13-18 years old) with PTSD and 24 age-matched healthy controls. The volume of the region CA2-3/DG region was significantly smaller in the PTSD group compared to controls in both hemispheres. No other significant difference was found for other subfields. Moreover, the volume of the left CA2-3/DG was negatively correlated with the intrusion score (as measured by the Impact of Events Scale-Revised) in the PTSD group. To conclude, an alteration in the hippocampal subregion CA2-3/DG, known to resolve interferences between new and similar stored memories, could participate in the apparition of intrusive trauma memories in adolescents with PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.