ArticleHuman brain mapping2019
Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Stability of associations between neuroticism and microstructural asymmetry of the cingulum during late childhood and adolescence: Insights from a longitudinal study with up to 11 waves.Human brain mapping · 2023Article
- Parental education, cognition and functional connectivity of the salience network.Scientific reports · 2023Article
- Association of Maternal Depression During Pregnancy and Recent Stress With Brain Age Among Adult Offspring.JAMA network open · 2023Article
- White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions.Depression and anxiety · 2022Article
- Socioeconomic and cognitive roots of trait anxiety in young adults.Social cognitive and affective neuroscience · 2022Article
- Sex-specific vulnerability to depressive symptoms across adolescence and during the COVID-19 pandemic: The role of the cingulum bundle.JCPP advances · 2022Article
- Exposure to prenatal maternal distress and infant white matter neurodevelopment.Development and psychopathology · 2021Article
- Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood.Human brain mapping · 2020Article
- Amygdala-Prefrontal Structural Connectivity Mediates the Relationship between Prenatal Depression and Behavior in Preschool Boys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort.Human brain mapping · 2019Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Depression is the leading cause of years lost due to disability worldwide. Still, the mechanisms underlying its development are not well understood. This study aimed to evaluate white-matter properties associated with depressive symptomatology in young adulthood and their developmental origins. Diffusion tensor imaging and assessment of depressive symptomatology were conducted in 128 young adults (47% male, age 23-24) from a prenatal birth cohort (European Longitudinal Study of Pregnancy and Childhood). For a subset of these individuals, the database included information on prenatal stress (n = 93) and depressive symptoms during adolescence (assessed repeatedly at age 15 and 19). Depressive symptoms in young adulthood were associated with lower fractional anisotropy in the left and right cingulum and higher fractional anisotropy in the right corticospinal tract and superior longitudinal fasciculus. Further analyses revealed that prenatal stress and depressive symptomatology during adolescence were independent predictors of altered white-matter properties in the cingulum in young adulthood. We conclude that typically developing young adults with more depressive symptoms already exhibit tract-specific alterations in white-matter properties and that prenatal stress and depressive symptomatology during adolescence might contribute to their development.
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