ArticleHuman brain mapping2019
Directed functional connections underlying spontaneous brain activity.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
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- Effects of Manual Acupuncture Versus Sham Acupuncture in patients with Post-Stroke Depression: A Randomized Clinical Trial.Neurology and therapy · 2024Article
- Multi-scale spiking network model of human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Information theory-based direct causality measure to assess cardiac fibrillation dynamics.Journal of the Royal Society, Interface · 2023Article
- Alzheimer's Disease: Insights from Large-Scale Brain Dynamics Models.Brain sciences · 2023Review
- Inter-individual variability during neurodevelopment: an investigation of linear and nonlinear resting-state EEG features in an age-homogenous group of infants.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Connectivity Analysis in EEG Data: A Tutorial Review of the State of the Art and Emerging Trends.Bioengineering (Basel, Switzerland) · 2023Review
- Decreased Functional Connectivity of Brain Networks in the Alpha Band after Sleep Deprivation Is Associated with Decreased Inhibitory Control in Young Male Adults.International journal of environmental research and public health · 2023Article
- Dynamic networks differentiate the language ability of children with cochlear implants.Frontiers in neuroscience · 2023Article
- Brain mechanisms of mental processing: from evoked and spontaneous brain activities to enactive brain activity.Psychoradiology · 2023Review
- Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis.Cognitive neurodynamics · 2022Article
- Coupling of spatial and directional functional network connectivity reveals a physiological basis for salience network hubs in asthma.Brain imaging and behavior · 2022Article
- Transcranial stimulation of alpha oscillations up-regulates the default mode network.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial.Frontiers in aging neuroscience · 2022Article
- Case Report: Laser Ablation Guided by State of the Art Source Imaging Ends an Adolescent's 16-Year Quest for Seizure Freedom.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Neuroimaging studies have shown that spontaneous brain activity is characterized as changing networks of coherent activity across multiple brain areas. However, the directionality of functional interactions between the most active regions in our brain at rest remains poorly understood. Here, we examined, at the whole-brain scale, the main drivers and directionality of interactions that underlie spontaneous human brain activity by applying directed functional connectivity analysis to electroencephalography (EEG) source signals. We found that the main drivers of electrophysiological activity were the posterior cingulate cortex (PCC), the medial temporal lobes (MTL), and the anterior cingulate cortex (ACC). Among those regions, the PCC was the strongest driver and had both the highest integration and segregation importance, followed by the MTL regions. The driving role of the PCC and MTL resulted in an effective directed interaction directed from posterior toward anterior brain regions. Our results strongly suggest that the PCC and MTL structures are the main drivers of electrophysiological spontaneous activity throughout the brain and suggest that EEG-based directed functional connectivity analysis is a promising tool to better understand the dynamics of spontaneous brain activity in healthy subjects and in various brain disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.