ArticleClinical drug investigation2019
Neuropsychological Assessment in Elderly Men with Benign Prostatic Hyperplasia Treated with Dutasteride.
Article in Clinical drug investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Mindfulness, Compassion, and Self-Compassion Among Health Care Professionals: What's New? A Systematic Review.Frontiers in psychology · 2020Pooled it
- Alexithymia and Inflammatory Bowel Disease: A Systematic Review.Frontiers in psychology · 2020Pooled it
- The Relationship Between Alexithymia and Type 2 Diabetes: A Systematic Review.Frontiers in psychology · 2020Pooled it
- Interrelations between clinical-psychological features and bone mineral density changes in post-menopausal women undergoing anti-osteoporotic treatment: a two-year follow-up.Frontiers in endocrinology · 2023Article
- Effects of dutasteride on sex hormones and cerebrospinal steroids in patients treated for benign prostatic hyperplasia.Endocrine · 2021Article
- Psychological Factors as Determinants of Chronic Conditions: Clinical and Psychodynamic Advances.Frontiers in psychology · 2021Article
- Alexithymia, Emotional Distress, and Perceived Quality of Life in Patients With Hashimoto's Thyroiditis.Frontiers in psychology · 2021Article
- The Role of Suppression and the Maintenance of Euthymia in Clinical Settings.Frontiers in psychology · 2021Article
- Retrospective Analyses of Psychological Distress and Defense Style Among Cancer Patients.Clinical neuropsychiatry · 2020Article
- Preliminary Reliability and Validity of the DMRS-SR-30, a Novel Self-Report Measure Based on the Defense Mechanisms Rating Scales.Frontiers in psychiatry · 2020Article
- Mindfulness, Age and Gender as Protective Factors Against Psychological Distress During COVID-19 Pandemic.Frontiers in psychology · 2020Article
- Dispositional Optimism and Context Sensitivity: Psychological Contributors to Frailty Status Among Elderly Outpatients.Frontiers in psychology · 2020Article
- Clinical Psychological Figures in Healthcare Professionals: Resilience and Maladjustment as the "Cost of Care".Frontiers in psychology · 2020Article
- Going Beyond the Visible in Type 2 Diabetes Mellitus: Defense Mechanisms and Their Associations With Depression and Health-Related Quality of Life.Frontiers in psychology · 2020Article
- Quality of life and psychological functioning in postmenopausal women undergoing aromatase inhibitor treatment for early breast cancer.PloS one · 2020Article
- Editorial: Psychological Factors as Determinants of Medical Conditions.Frontiers in psychology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveBenign prostatic hyperplasia (BPH) is a common disease found in elderly men and 5α-reductase (5α-R) inhibitors are a commonly used treatment option. 5α-reduced steroids are compounds that play a role in several functions across different organs and systems. In the adult brain, 5α-R accounts for neuroactive steroid production. Whether neuropsychological impairment could be due to dutasteride treatment, a 5α-R inhibitor affecting the production of dihydrotestosterone (DHT), is still unknown. The aim of our study was to investigate neuropsychological features in men receiving dutasteride.
methodsThe Mini Mental State Examination (MMSE), the Clock Drawing Test (CDT), the Frontal Assessment Battery (FAB), the Hamilton Anxiety Rating Scale (HAM-A), the Beck Depression Inventory second edition (BDI-II) and the Short Form-12 (SF-12) questionnaire were administered in order to explore both cognitive impairment and psychological features.
resultsIn a sample of BPH patients (n = 40; mean age 71.4 ± 7.4 years), men receiving dutasteride showed no significant differences during the neuropsychological assessment in comparison with an age-matched control group, consisting of BPH men not receiving dutasteride (p < 0.05). No significant associations were recorded between treatment duration and any of the administered tests.
conclusionsThis is the first study investigating the neuropsychological features in dutasteride users. Our preliminary data are consistent with the safety of dutasteride under a mental profile.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.