Evidence map›Paper›PMID 30367392›Full record

ArticleJournal of physiology and biochemistry2018

Variations in adrenal gland medulla and dopamine effects induced by the lack of Irs2.

Leonardo Catalano-Iniesta, María Carmen Iglesias-Osma, Virginia Sánchez-Robledo, Marta Carretero-Hernández, Enrique J Blanco, José Carretero, María José García-Barrado

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Leonardo Catalano-IniestaDepartment of Physiology and Pharmacology, INCyL and IBSAL, Faculty of Medicine, University of Salamanca, Avda. Alfonso X el Sabio, s/n, E-37007, Salamanca, Spain.
María Carmen Iglesias-OsmaDepartment of Physiology and Pharmacology, INCyL and IBSAL, Faculty of Medicine, University of Salamanca, Avda. Alfonso X el Sabio, s/n, E-37007, Salamanca, Spain.
Virginia Sánchez-RobledoDepartment of Physiology and Pharmacology, INCyL and IBSAL, Faculty of Medicine, University of Salamanca, Avda. Alfonso X el Sabio, s/n, E-37007, Salamanca, Spain.
Marta Carretero-HernándezLaboratory of Neuroendocrinology, Institute of Neurosciences of Castilla y León (INCyL), University of Salamanca, Salamanca, Spain.
Enrique J BlancoLaboratory of Neuroendocrinology, Institute of Neurosciences of Castilla y León (INCyL), University of Salamanca, Salamanca, Spain.
José CarreteroLaboratory of Neuroendocrinology, Institute of Neurosciences of Castilla y León (INCyL), University of Salamanca, Salamanca, Spain.
María José García-BarradoDepartment of Physiology and Pharmacology, INCyL and IBSAL, Faculty of Medicine, University of Salamanca, Avda. Alfonso X el Sabio, s/n, E-37007, Salamanca, Spain. barrado@usal.es.
Instituto de Estudios de Ciencias de la Salud de Castilla y León · ESInstituto de Investigación Biomédica de Salamanca · ESUniversidad de Salamanca · ES

Funding

Universidad de Salamanca 2017/00103/001
6 · The paper itself

Abstract

The adrenomedullary chromaffin cells' hormonal pathway has been related to the pathophysiology of diabetes mellitus. In mice, the deletion of insulin receptor substrate type 2 (Irs2) causes peripheral insulin resistance and reduction in β-cell mass, leading to overt diabetes, with gender differences on adrenergic signaling. To further unravel the relevance of Irs2 on glycemic control, we analyzed in adult Irs2 deficient (Irs2

Indexed as

Insulin SecretionAdipocytes, WhiteAdrenal MedullaAnimalsApoptosisCells, CulturedChromaffin CellsDopamineFemaleHyperinsulinismInsulin Receptor Substrate ProteinsIn Vitro TechniquesIslets of LangerhansLipolysisMaleMice, Inbred C57BLDopamineInsulin Receptor Substrate ProteinsIrs2 protein, mouseTyrosine 3-MonooxygenaseAdipocytesAdrenal chromaffin cellsApoptosisBeta-cellsDopamineGlycerol releaseInsulin secretionProliferationTyrosine hydroxylase

Identifiers

PMID30367392
OpenAlexW2898611794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.