Evidence map›Paper›PMID 30367380›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020

Comparison of two dipyridamole infusion protocols for myocardial perfusion imaging in subjects with low likelihood of significant obstructive coronary artery disease.

Francois Harel, Vincent Finnerty, Sébastien Authier, Matthieu Pelletier-Galarneau

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. The potential of regional myocardial blood flow measurement with SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  4. Dipyridamole infusion protocols for absolute myocardial blood flow quantitation by PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Francois HarelDepartment of Radiology and Nuclear Medicine, Montreal Heart Institute, 5000 Belanger, Montreal, QC, H1T 1C8, Canada.
Vincent FinnertyDepartment of Radiology and Nuclear Medicine, Montreal Heart Institute, 5000 Belanger, Montreal, QC, H1T 1C8, Canada.
Sébastien AuthierDepartment of Radiology and Nuclear Medicine, Montreal Heart Institute, 5000 Belanger, Montreal, QC, H1T 1C8, Canada.
Matthieu Pelletier-GalarneauDepartment of Radiology and Nuclear Medicine, Montreal Heart Institute, 5000 Belanger, Montreal, QC, H1T 1C8, Canada. mattgalarneau@gmail.com.
Montreal Heart Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial perfusion imaging (MPI) with positron emission tomography allows accurate measurements of myocardial blood flow (MBF). Stress MBF thresholds have been proposed to provide diagnostic and prognostic information in different pathology. Most studies relying on dipyridamole use a 5-minute infusion protocol, while current guidelines recommend a 4-minute infusion. The purpose of this study is to compare the effects of different dipyridamole infusion times on stress MBF.

methodsThe charts of 2,207 patients who underwent rubidium-82 MPI were retrospectively reviewed and 147 subjects with low likelihood of significant coronary artery disease (CAD) defined as calcium score = 0, body mass index < 45 kg·m

resultsStress MBF (3.23±0.76 vs 3.02±0.71 mL·min

conclusionsThe 4-minute and 5-minute dipyridamole infusion protocols produce comparable myocardial flow response, hemodynamic changes, and symptoms, in subjects with low likelihood of significant obstructive CAD.

Indexed as

Myocardial Perfusion ImagingPositron-Emission TomographyAdultAgedCoronary Artery DiseaseCoronary CirculationDipyridamoleDrug Administration ScheduleExercise TestFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsRubidium RadioisotopesDipyridamoleRubidium-82Rubidium RadioisotopesVasodilator Agentsdipyridamolemyocardial blood flowmyocardial flow reserveMyocardial perfusion imagingpositron emission tomography, PET/CTrubidium

Identifiers

PMID30367380
OpenAlexW2898604876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.