Evidence map›Paper›PMID 30367159›Full record

ReviewPediatric research2019

Cortical interneuron function in autism spectrum condition.

Jason W Lunden, Madel Durens, Andre W Phillips, Michael W Nestor

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Cortical control of chandelier cells in neural codes.Frontiers in cellular neuroscience · 2022
    Pooled it
  2. Review
  3. Intermittent Fasting andNutrients · 2026
    Article
  4. Review
  5. Article
  6. Joint analysis ofNAR genomics and bioinformatics · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jason W LundenHussman Institute for Autism, 801W. Baltimore St., Suite 301, Baltimore, MD, 21201, USA.
Madel DurensHussman Institute for Autism, 801W. Baltimore St., Suite 301, Baltimore, MD, 21201, USA.
Andre W PhillipsHussman Institute for Autism, 801W. Baltimore St., Suite 301, Baltimore, MD, 21201, USA.
Michael W NestorHussman Institute for Autism, 801W. Baltimore St., Suite 301, Baltimore, MD, 21201, USA. mnestor@hussmanautism.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cortical interneurons (INs) are a diverse group of neurons that project locally and shape the function of neural networks throughout the brain. Multiple lines of evidence suggest that a proper balance of glutamate and GABA signaling is essential for both the proper function and development of the brain. Dysregulation of this system may lead to neurodevelopmental disorders, including autism spectrum condition (ASC). We evaluate the development and function of INs in rodent and human models and examine how neurodevelopmental dysfunction may produce core symptoms of ASC. Finding common physiological mechanisms that underlie neurodevelopmental disorders may lead to novel pharmacological targets and candidates that could improve the cognitive and emotional symptoms associated with ASC.

Indexed as

AnimalsAutism Spectrum DisorderCerebral CortexElectroencephalographygamma-Aminobutyric AcidGlutamic AcidHumansInduced Pluripotent Stem CellsInterneuronsgamma-Aminobutyric AcidGlutamic Acid

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.