ArticleScientific reports2018
Effects of circadian misalignment on sleep in mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Sleep Identification Enabled by Supervised Training Algorithms (SIESTA): An Open-Source Platform for Automatic Sleep Staging of Rodent Electrocorticographic and Electromyographic Data.Journal of biological rhythms · 2025Article
- Mapping the Neural Basis of Wake Onset Regularity and Its Effects on Sleep Quality and Positive Affect.Clocks & sleep · 2025Article
- Timing Mechanisms for Circadian Seizures.Clocks & sleep · 2024Review
- Long-term night-shift work is associated with accelerates brain aging and worsens N3 sleep in female nurses.Sleep medicine · 2024Article
- Brain structural correlates of subjective sleepiness and insomnia symptoms in shift workers.Frontiers in neuroscience · 2024Article
- The Impact of Light-Dark Cycle Alteration on the Acceleration of Type 1 Diabetes in NOD Mice Model.Nature and science of sleep · 2024Article
- The Interactive Role of Sleep and Circadian Rhythms in Episodic Memory in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Review
- Reversible suppression of circadian-driven locomotor rhythms in mice using a gradual fragmentation of the day-night cycle.Scientific reports · 2023Article
- Sleep timing and the circadian clock in mammals: Past, present and the road ahead.Seminars in cell & developmental biology · 2022Review
- Circadian rhythm disruption results in visual dysfunction.FASEB bioAdvances · 2022Article
- Article
- Brain-derived neurotrophic factor Val66Met polymorphism modulates the effects of circadian desynchronization on activity and sleep in male mice.Frontiers in neuroscience · 2022Article
- Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Modulation of recognition memory performance by light and its relationship with cortical EEG theta and gamma activities.Biochemical pharmacology · 2021Article
- Associations of midpoint of sleep and night sleep duration with type 2 diabetes mellitus in Chinese rural population: the Henan rural cohort study.BMC public health · 2021Article
- Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.Cellular and molecular life sciences : CMLS · 2021Review
- Physiological and cognitive consequences of a daily 26 h photoperiod in a primateProceedings. Biological sciences · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythms and sleep-wake history determine sleep duration and intensity, and influence subsequent waking. Previous studies have shown that T cycles - light-dark (LD) cycles differing from 24 h - lead to acute changes in the daily amount and distribution of waking and sleep. However, little is known about the long-term effects of T cycles. Here we performed continuous 10 day recording of electroencephalography (EEG), locomotor activity and core body temperature in C57BL/6 mice under a T20 cycle, to investigate spontaneous sleep and waking at baseline compared with when the circadian clock was misaligned and then re-aligned with respect to the external LD cycle. We found that the rhythmic distribution of sleep was abolished during misalignment, while the time course of EEG slow wave activity (1-4 Hz) was inverted compared to baseline. Although the typical light-dark distribution of NREM sleep was re-instated when animals were re-aligned, slow wave activity during NREM sleep showed an atypical increase in the dark phase, suggesting a long-term effect of T cycles on sleep intensity. Our data show that circadian misalignment results in previously uncharacterised long-term effects on sleep, which may have important consequences for behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.