Evidence map›Paper›PMID 30367097›Full record

ArticleScientific reports2018

Investigating the Ca

Frans Vinberg, Vladimir J Kefalov

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Increasing CaCell death and differentiation · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Frans VinbergOphthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA. frans.vinberg@hsc.utah.edu.ORCID http://orcid.org/0000-0003-3439-4979
Vladimir J KefalovOphthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.
Washington University in St. Louis · US

Funding

WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 1985 to 2026
$18.4M
MECHANISMS OF ADAPTATION IN MAMMALIAN CONESR01EY019312 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV · 2009 to 2017
$3.3M
PIGMENT DEPHOSPHORYLATION IN MAMMALIAN ROD AND CONE PHOTORECEPTORSR01EY025696 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV · 2016 to 2019
$1.5M
CALCIUM HOMEOSTASIS IN MAMMALIAN ROD AND CONE PHOTORECEPTORSR01EY027387 · NEI · WASHINGTON UNIVERSITY · PI CHEN, JEANNIE, KEFALOV, VLADIMIR JIVKOV · 2017 to 2020
$1.4M
Assessment of Retinal Function in Health and Disease From Mouse To HumanR00EY026651 · NEI · UNIVERSITY OF UTAH · PI VINBERG, FRANS · 2017 to 2019
$722k
ASSESSMENT OF RETINAL FUNCTION IN HEALTH AND DISEASE FROM MOUSE TO HUMANK99EY026651 · NEI · WASHINGTON UNIVERSITY · PI VINBERG, FRANS · 2016 to 2017
$190k
NEI NIH HHS K99 EY026651NEI NIH HHS P30 EY002687NEI NIH HHS R00 EY026651NEI NIH HHS R01 EY019312NEI NIH HHS R01 EY025696NEI NIH HHS R01 EY027387
6 · The paper itself

Abstract

Vision is mediated by two types of photoreceptors: rods, enabling vision in dim light; and cones, which function in bright light. Despite many similarities in the components of their respective phototransduction cascades, rods and cones have distinct sensitivity, response kinetics, and adaptation capacity. Cones are less sensitive and have faster responses than rods. In addition, cones can function over a wide range of light conditions whereas rods saturate in moderately bright light. Calcium plays an important role in regulating phototransduction and light adaptation of rods and cones. Notably, the two dominant Ca

Indexed as

LightAdaptation, OcularAnimalsCalciumCyclic GMPGuanylate Cyclase-Activating ProteinsIonsKineticsMiceMice, KnockoutRecoverinRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor CellsUp-RegulationCalciumCyclic GMPGuanylate Cyclase-Activating ProteinsIonsRecoverin

Identifiers

PMID30367097
PMCPMC6203770
OpenAlexW2897188548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.