SynthesisNature communications2018
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 11 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 11 pooled it
13.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
163 citing papers in PubMed, 11 syntheses or guidelines pooled it, 288 citations in OpenAlex.
- Genome-wide association study and polygenic risk prediction of hypothyroidism.Nature genetics · 2025Pooled it
- Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.Nature communications · 2024Pooled it
- No causal relationship between thyroid function and Parkinson's disease: A bidirectional Mendelian randomization study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.Nature communications · 2024Pooled it
- Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2023Pooled it
- Mendelian randomization study of thyroid function and anti-Müllerian hormone levels.Frontiers in endocrinology · 2023Pooled it
- Genetically predicted alterations in thyroid function are associated with the risk of benign prostatic disease.Frontiers in endocrinology · 2023Pooled it
- Pooled it
- Causal associations between thyroid dysfunction and COVID-19 susceptibility and severity: A bidirectional Mendelian randomization study.Frontiers in endocrinology · 2022Pooled it
- Epigenome-Wide Association Study of Thyroid Function Traits Identifies Novel Associations of fT3 With KLF9 and DOT1L.The Journal of clinical endocrinology and metabolism · 2021Pooled it
- Causal associations of thyroid function and dysfunction with overall, breast and thyroid cancer: A two-sample Mendelian randomization study.International journal of cancer · 2020Pooled it
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Arrhythmia and cardiomyopathy risk in Taiwan with complementary biobank evidence on thyroid genetic susceptibility: an integrative population-based framework.Endocrine connections · 2026Article
- Systematic proteomic analysis of neuroimaging metrics identifies therapeutic targets for pituitary neuroendocrine.NPJ systems biology and applications · 2026Article
- Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction.PloS one · 2026Article
- The gut-thyroid axis: physiological regulation of barrier function, microbiota, endocrine signaling and the consequences on energy metabolism.Frontiers in physiology · 2026Review
- From Tradition to Future: Pathophysiological Mechanisms and Clinical Research Progress in the Treatment of Hypothyroidism with Traditional Chinese Medicine--A Narrative Review.Therapeutics and clinical risk management · 2026Review
- Genetics of Thyroid Function: Relevance for Biology and Disease Management.The Journal of clinical endocrinology and metabolism · 2025Review
- Thyroid disease and breast cancer, benign breast neoplasm: a two-sample Mendelian randomization study.BMC women's health · 2025Article
- Article
103 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
129 authors at 20 institutions in 14 countries.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de.ORCID http://orcid.org/0000-0002-8309-094X
Layal ChakerErasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.
Stefan GroenewegErasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.
Yong LiDepartment of Biometry, Epidemiology and Medical Bioinformatics, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Celia Di MunnoErasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.
Caterina BarbieriDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Ulla T SchultheissDepartment of Biometry, Epidemiology and Medical Bioinformatics, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Michela TragliaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Tarunveer S AhluwaliaSteno Diabetes Center Copenhagen, Gentofte, Denmark.ORCID http://orcid.org/0000-0002-7464-3354
Masato AkiyamaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Emil Vincent R AppelNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7704-6611
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alice ArnoldDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Arne AstrupDepartment of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8968-8996
Marian BeekmanMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-0585-6206
John P BeilbyPathwest Laboratory Medicine WA, Nedlands, WA, 6009, Australia.ORCID http://orcid.org/0000-0002-4915-2254
Sofie BekaertBimetra, Clinical Research Center Ghent, Ghent University Hospital, Ghent, Belgium.
Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center, 1200 Pressler Street, Houston, TX, 77030, USA.
Suzanne J BrownDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.
Marc De BuyzereDepartment of Cardiology, Ghent University Hospital, Ghent, Belgium.
Purdey J CampbellDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.
Graziano CeresiniDepartment of Medicine and Surgery, University of Parma, University Hospital of Parma, Parma, Italy.
Charlotte CerqueiraCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato, Monserrato, Italy.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Joris DeelenMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Kai-Uwe EckardtDepartment of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany.
Arif B EkiciInstitute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID http://orcid.org/0000-0001-6099-7066
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Luigi FerrrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Tom FiersDepartment of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium.
Edoardo FiorilloIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato, Monserrato, Italy.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
Caroline S FoxNational Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA, USA.
Christian FuchsbergerInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy.
Tessel E GaleslootRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Christian GiegerHelmholtz Zentrum München, Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany.
Martin GögeleInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy.
Alessandro De GrandiInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5526-1070
Karin Halina GreiserGerman Research Centre Division of Cancer Epidemiology, Heidelberg, Germany.
Kadri HaljasDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Diana van HeemstLeiden University Medical Center, Geriatrics and Gerontology, Leiden, The Netherlands.
Martin den HeijerVrije Universiteit Medisch Centrum, Amsterdam, The Netherlands.
Andrew A HicksInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy.ORCID http://orcid.org/0000-0001-6320-0411
Wouter den HollanderDepartment of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Jennie HuiPathwest Laboratory Medicine WA, Nedlands, WA, 6009, Australia.
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Till IttermannInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Richard A JensenDepartment of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Jiaojiao JingDepartment of Biometry, Epidemiology and Medical Bioinformatics, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Eero KajantieNational Institute for Health and Welfare, Helsinki, Finland.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Elisa KasbohmInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Jean-Marc KaufmanDepartment of Endocrinology, Ghent University Hospital, Ghent, Belgium.
Lambertus A KiemeneyRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Margreet KloppenburgDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Florian KronenbergDepartment of Medical Genetics, Division of Genetic Epidemiology, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-2229-1120
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Jari LahtiDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4310-5297
Bruno LapauwDepartment of Endocrinology, Ghent University Hospital, Ghent, Belgium.
Shuo LiDepartment of Biostatistics, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2331-2448
David C M LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0544-7368
Lifelines Cohort Study
Ee Mun LimPathwest Laboratory Medicine WA, Nedlands, WA, 6009, Australia.
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0994-0184
Michela MarinaDepartment of Medicine and Surgery, University of Parma, University Hospital of Parma, Parma, Italy.
Deborah MascalzoniInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy.ORCID http://orcid.org/0000-0003-4156-1464
Koichi MatsudaDepartment of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Daniel MedenwaldInstitute for Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Christa MeisingerHelmholtz Zentrum München, Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany.
Ingrid MeulenbeltDepartment of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-7786-7081
Tim De MeyerDepartment of Data Analysis and Mathematical Modelling, Ghent University, Ghent, Belgium.
Henriette E Meyer Zu SchwabedissenDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Rafael MikolajczykInstitute for Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Matthijs MoedMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Romana T Netea-MaierDepartment of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-9603-0460
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-0311-8472
Mauro PalaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato, Monserrato, Italy.
Cristian PattaroInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Astrid PetersmannInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Eleonora PorcuIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato, Monserrato, Italy.
Iris PostmusDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands.
Peter P PramstallerInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Yolande F M RamosDepartment of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-1459-413X
Rajesh RawalHelmholtz Zentrum München, Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany.
Paul RedmondDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
J Brent RichardsLady Davis Institute, Jewish General Hospital, Montreal, QC, H3T 1E2, Canada.ORCID http://orcid.org/0000-0002-3746-9086
Ernst R RietzschelBiobanking and Cardiovascular Epidemiology, Ghent University Hospital, Ghent, Belgium.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Greet RoefDepartment of Endocrinology, Ghent University Hospital, Ghent, Belgium.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Cinzia F SalaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
David SchlessingerLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Elizabeth SelvinDepartment of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
P Eline SlagboomMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Nicole SoranzoThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH, UK.ORCID http://orcid.org/0000-0003-1095-3852
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Timothy D SpectorThe Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Campus, Lambeth Palace Road, London, SE1 7EH, UK.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
David J StottInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
Youri TaesAZ Sint Jan Brugge, Brugge, Belgium.
Daniel TaliunInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Betina ThuesenCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
Daniel TillerChair of Epidemiology, Ludwig-Maximilians-Universität München, at UNIKA-T Augsburg, Augsburg, Germany.
Daniela TonioloDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Andre G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
W Edward VisserErasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.
John P WalshDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.
Scott G WilsonDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.
Bruce H R WolffenbuttelDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Qiong YangDepartment of Biostatistics, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Hou-Feng ZhengDiseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University and Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Anne CappolaDivision of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Robin P PeetersErasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.
Silvia NaitzaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato, Monserrato, Italy.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Serena SannaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato, Monserrato, Italy.
Anna KöttgenDepartment of Biometry, Epidemiology and Medical Bioinformatics, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-4671-3714
Theo J VisserErasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.
Marco MediciErasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.
Eurac Research · ITLeiden University Medical Center · NLErasmus MC · NLUniversity of Copenhagen · DKGhent University Hospital · BEUniversity Medical Center Groningen · NLThe University of Western Australia · AUUniversitätsmedizin Greifswald · DEUniversity of Augsburg · DEUniversity of Helsinki · FIBoston University · USFrederiksberg Hospital · DKJohns Hopkins University · USKing's College London · GBRadboud University Nijmegen · NLSir Charles Gairdner Hospital · AUUniversity of Freiburg · DEUniversity of Parma · ITFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHelmholtz Zentrum München · DE
Funding
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MAging-related Traits and Disease Risk Factors in a Sardinian Population CohortZIAAG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2021
$5.7MThe Aging Genome Association Study "AGE-GAIN"ZIAAG000965 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$4.0MBiotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council MR/K026992/1NHLBI NIH HHS R01 HL105756NHLBI NIH HHS U01 HL130114
Abstract
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves' disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets.
Indexed as
2-Aminoadipate TransaminaseAnimalsBiological TransportChlorocebus aethiopsCOS CellsGene Expression RegulationGenome-Wide Association StudyHumansHyperthyroidismHypothyroidismPolymorphism, Single NucleotideRisk FactorsSodium-Phosphate Cotransporter Proteins, Type IThyroid GlandThyroid HormonesThyrotropin2-Aminoadipate TransaminaseSLC17A4 protein, humanSodium-Phosphate Cotransporter Proteins, Type IThyroid HormonesThyrotropin
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