ArticleNature communications2018
Long time-scales in primate amygdala neurons support aversive learning.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Feasibility of Integrating Real-Time fMRI Neurofeedback with rTMS: Study Design, Preliminary Results, and Technical Challenges.Aperture neuro · 2026Article
- The influence of emotion on temporal context models.Cognition & emotion · 2025Review
- Detection of latent brain states from spontaneous neural activity in the amygdala.PLoS computational biology · 2025Article
- Detection of latent brain states from baseline neural activity in the amygdala.bioRxiv : the preprint server for biology · 2024Article
- Functional connectivity of amygdala subnuclei in PTSD: a narrative review.Molecular psychiatry · 2023Review
- Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques.Current research in neurobiology · 2023Review
- Marmosets confirm that context is king.Neuron · 2022Article
- The Cholinergic Basal Forebrain Links Auditory Stimuli with Delayed Reinforcement to Support Learning.Neuron · 2019Article
- Embracing Complexity in Defensive Networks.Neuron · 2019Review
- A neural microcircuit model for a scalable scale-invariant representation of time.Hippocampus · 2019Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associative learning forms when there is temporal relationship between a stimulus and a reinforcer, yet the inter-trial-interval (ITI), which is usually much longer than the stimulus-reinforcer-interval, contributes to learning-rate and memory strength. The neural mechanisms that enable maintenance of time between trials remain unknown, and it is unclear if the amygdala can support time scales at the order of dozens of seconds. We show that the ITI indeed modulates rate and strength of aversive-learning, and that single-units in the primate amygdala and dorsal-anterior-cingulate-cortex signal confined periods within the ITI, strengthen this coding during acquisition of aversive-associations, and diminish during extinction. Additionally, pairs of amygdala-cingulate neurons synchronize during specific periods suggesting a shared circuit that maintains the long temporal gap. The results extend the known roles of this circuit and suggest a mechanism that maintains trial-structure and temporal-contingencies for learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.