ArticleNature communications2018
Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 85 citations in OpenAlex.
- Neurofeedback and attention modulate somatosensory alpha oscillations but not pain perception.PLoS biology · 2025Trial
- Nociception index-monitored extubation is associated with improved hemodynamic stability and recovery efficiency in the post-anesthesia care unit: a single-center randomized controlled trial.Journal of clinical monitoring and computing · 2026Article
- Neural encoding of pain is robust within but unstable between individuals.PLoS biology · 2026Article
- Placebo Effect on Pain-Related Autonomic Responses in a State of Experimentally-Induced Sensitization.European journal of pain (London, England) · 2026Observational
- Dynamic expectation strength and precision shape human pain perception through shared and dissociable α-oscillatory mechanisms.PLoS biology · 2026Article
- Perceived sensorimotor synchrony enhances pain modulation and attenuates laser-evoked potentials.Communications biology · 2025Article
- Neural variability reliably encodes interindividual differences in the perception of pain intensity.PLoS biology · 2025Article
- A comprehensive EEG dataset of laser-evoked potentials for pain research.Scientific data · 2025Article
- The analgesic effect and neural mechanism of spicy food intake.Social cognitive and affective neuroscience · 2025Article
- Nocebo Effect on Pain-Related Autonomic Responses in a State of Experimentally-Induced Sensitization.European journal of pain (London, England) · 2025Article
- Physiological Sensor Modality Sensitivity Test for Pain Intensity Classification in Quantitative Sensory Testing.Sensors (Basel, Switzerland) · 2025Article
- Objective Pain Assessment Using Deep Learning Through EEG-Based Brain-Computer Interfaces.Biology · 2025Article
- Physiological framework for non-invasive detection and objective nociception activity in communicative patients: a pilot case study.Frontiers in physiology · 2025Article
- The Investigation of the Relationship Between Individual Pain Perception, Brain Electrical Activity, and Facial Expression Based on Combined EEG and Facial EMG Analysis.Journal of pain research · 2025Article
- Neuroimaging-based evidence for sympathetic correlation between brain activity and peripheral vasomotion during pain anticipation.Scientific reports · 2024Article
- Intact painful sensation but enhanced non-painful sensation in individuals with autistic traits.Frontiers in psychiatry · 2024Article
- Entangled brains and the experience of pains.Frontiers in psychology · 2024Review
- Deciphering Authentic Nociceptive Thalamic Responses in Rats.Research (Washington, D.C.) · 2024Article
- The influence of aggressive exercise on responses to self-perceived and others' pain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Priming of the autonomic nervous system after an experimental human pain model.Journal of neurophysiology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Pain is a complex phenomenon involving perceptual, motor, and autonomic responses, but how the brain translates noxious stimuli into these different dimensions of pain is unclear. Here, we assessed perceptual, motor, and autonomic responses to brief noxious heat stimuli and recorded brain activity using electroencephalography (EEG) in humans. Multilevel mediation analysis reveals that each pain dimension is subserved by a distinct pattern of EEG responses and, conversely, that each EEG response differentially contributes to the different dimensions of pain. In particular, the translation of noxious stimuli into autonomic and motor responses involved the earliest N1 wave, whereas pain perception was mediated by later N2 and P2 waves. Gamma oscillations mediated motor responses rather than pain perception. These findings represent progress towards a mechanistic understanding of the brain processes translating noxious stimuli into pain and suggest that perceptual, motor, and autonomic dimensions of pain are partially independent rather than serial processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.