ArticleThe Journal of biological chemistry2018
FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.
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Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 45 citations in OpenAlex.
- Alternative polyadenylation links RNA processing to iron metabolism in human erythropoiesis.Nucleic acids research · 2026Article
- Current research on the HIF-2α-EPO-Hb axis in hypoxic environments: from molecular mechanisms to clinical.Frontiers in medicine · 2026Review
- Hinokitiol as a Promising Anticancer Agent: Mechanisms of Action, Potential in Combination Therapy, and Overcoming Chemoresistance.Current pharmaceutical design · 2026Review
- Integrative multi-omics analysis unveils the regulatory landscape of diabetic cardiomyopathy: from chromatin accessibility to transcript isoforms and epitranscriptome.Frontiers in endocrinology · 2026Article
- Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression.Blood advances · 2025Article
- FAM210B regulates iron homeostasis and sex-specific responses in stress erythropoiesis.Experimental hematology · 2025Article
- FAM210B Regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis.bioRxiv : the preprint server for biology · 2025Article
- Minimizing higher-order aggregation maximizes iron mobilization by small molecules.Nature chemical biology · 2024Article
- Multifaceted role of FAM210B in hepatocellular carcinoma: Implications for tumour progression, microenvironment modulation and therapeutic selection.Journal of cellular and molecular medicine · 2024Article
- Deletion of the Mitochondrial Membrane Protein Fam210b Is Associated with the Development of Systemic Lupus Erythematosus.International journal of molecular sciences · 2024Article
- A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans.Communications biology · 2024Article
- Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1.Molecular cancer therapeutics · 2023Article
- Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy.Experimental hematology & oncology · 2023Review
- Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy.Diabetology & metabolic syndrome · 2023Review
- Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular Carcinoma.Biomedicines · 2023Article
- Elucidation of the Role of FAM210B in Mitochondrial Metabolism and Erythropoiesis.Molecular and cellular biology · 2022Article
- Nucleosome destabilization by polyamines.Archives of biochemistry and biophysics · 2022Article
- Regulation of Heme Synthesis by Mitochondrial Homeostasis Proteins.Frontiers in cell and developmental biology · 2022Review
- Iron, Heme Synthesis and Erythropoietic Porphyrias: A Complex Interplay.Metabolites · 2021Review
- Using the Zebrafish as a Genetic Model to Study Erythropoiesis.International journal of molecular sciences · 2021Review
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Authors and funding
24 authors at 11 institutions in 1 country.
Yvette Y YienFrom the Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, yyien@udel.edu.
Jiahai Shithe Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Caiyong Chenthe Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Jesmine T M Cheungthe Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095.
Anthony S Grillothe Department of Chemistry and Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Rishna Shresthathe Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112.
Liangtao Lithe Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112.
Xuedi ZhangFrom the Department of Biological Sciences, University of Delaware, Newark, Delaware 19716.
Martin D Kafinathe Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Paul D Kingsleythe Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642.
Matthew J Kingthe Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Julien Ablainthe Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Hojun Lithe Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Leonard I Zonthe Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
James Palisthe Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642.
Martin D Burkethe Department of Chemistry and Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Daniel E Bauerthe Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Stuart H Orkinthe Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Carla M Koehlerthe Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095.
John D Phillipsthe Division of Hematology and Hematologic Malignancy, University of Utah School of Medicine, Salt Lake City, Utah 84112.
Jerry Kaplanthe Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112.
Diane M Wardthe Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112.
Harvey F Lodishthe Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Barry H Pawthe Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
University of Utah · USHarvard University · USDana-Farber Cancer Institute · USUniversity of California, Los Angeles · USUniversity of Illinois Urbana-Champaign · USUniversity of Rochester Medical Center · USWhitehead Institute for Biomedical Research · USBoston Children's Hospital · USBrigham and Women's Hospital · USMassachusetts Institute of Technology · USUniversity of Delaware · US
Funding
TRANSCRIPTION FACTOR GATA-1 IN TERMINAL ERYTHROID DEVELOPMENTP01HL032262 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI ORKIN, STUART H · 1985 to 2021
$38.9MSTRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4MTranscriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Liu · 2013 to 2026
$25.3MPorphyrias Consortium: SupplementU54DK083909 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DESNICK, ROBERT J · 2009 to 2023
$18.5MProteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6MBiogenesis of the mitochondrial inner membrane diversity supplementR01GM061721 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOEHLER, CARLA M · 2000 to 2025
$8.1MMolecular Prosthetics and Lego ChemistryR35GM118185 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Martin D Burke · 2016 to 2026
$6.6MA Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3MProject-002U54DK110805 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ORKIN, STUART H, ZON, LEONARD IRA · 2016 to 2020
$5.9MRNA trafficking in mitochondriaR01GM073981 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Carla M Koehler, MICHAEL A TEITELL · 2006 to 2026
$5.1MFACTORS REGULATING THE CELLULAR UPTAKE OF IRONR37DK030534 · NIDDK · UNIVERSITY OF UTAH · PI KAPLAN, JERRY · 2000 to 2009
$3.3MPORPHYRIN BIOSYNTHESIS IN NORMAL AND DISEASE STATESR01DK020503 · NIDDK · UNIVERSITY OF UTAH · PI PARKER, CHARLES J, PHILLIPS, JOHN DEARBORN · 1986 to 2012
$3.3MNCI NIH HHS P01 CA163222NHLBI NIH HHS P01 HL032262NHLBI NIH HHS R01 HL116364NIDDK NIH HHS F32 DK098866NIDDK NIH HHS K01 DK106156NIDDK NIH HHS K08 DK093705NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK020503NIDDK NIH HHS R01 DK030534NIDDK NIH HHS R01 DK070838NIDDK NIH HHS R01 DK071116NIDDK NIH HHS R03 DK118307NIDDK NIH HHS R37 DK030534NIDDK NIH HHS U54 DK083909NIDDK NIH HHS U54 DK110805NIDDK NIH HHS U54 DK110858NIGMS NIH HHS R01 GM061721NIGMS NIH HHS R01 GM073981NIGMS NIH HHS R35 GM118185NIH HHS R24 OD017870
Abstract
Erythropoietin (EPO) signaling is critical to many processes essential to terminal erythropoiesis. Despite the centrality of iron metabolism to erythropoiesis, the mechanisms by which EPO regulates iron status are not well-understood. To this end, here we profiled gene expression in EPO-treated 32D pro-B cells and developing fetal liver erythroid cells to identify additional iron regulatory genes. We determined that FAM210B, a mitochondrial inner-membrane protein, is essential for hemoglobinization, proliferation, and enucleation during terminal erythroid maturation.
Indexed as
AnimalsErythroid CellsErythropoiesisErythropoietinFerrochelataseHEK293 CellsHemeHumansIronMembrane ProteinsMiceMitochondriaMitochondrial MembranesMitochondrial ProteinsProtein TransportErythropoietinFAM210B protein, humanFerrochelataseHemeIronMembrane ProteinsMitochondrial Proteinscell metabolismerythrocyteerythropoiesishemeiron metabolismred blood cell
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