Evidence map›Paper›PMID 30366958›Full record

ReviewJournal of neurology, neurosurgery, and psychiatry2019

Brain mechanisms underlying apathy.

Campbell Le Heron, Clay B Holroyd, John Salamone, Masud Husain

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurology, neurosurgery, and psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 81 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 6 pooled it
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05505019 narecruitingnot on this mapstarted 2022, after this paper: background citation

The Role of a Personalized Music Intervention Towards Alleviating Apathy in Parkinson's Disease

TypeinterventionalSponsorUniversity of British ColumbiaRan2022 to 2026Enrolled50ConditionsParkinson Disease, ApathyArmsMusic listening, Podcast listening
NCT05669170 phase2not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluating Safety and Potential Benefit of Methylphenidate as a Symptomatic Treatment for Apathy in Veterans With Parkinson's Disease.

TypeinterventionalSponsorRalph H. Johnson VA Medical CenterRan2024 to 2028Enrolled60ConditionsParkinson Disease, ApathyArmsPsychosocial intervention, Methylphenidate
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 6 syntheses or guidelines pooled it, 181 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Trial
  8. Dopamine Modulates Dynamic Decision-Making during Foraging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Trial
  9. Article
  10. Working Memory Deficits in Hippocampal Amnesia are Associated with Apathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  11. Review
  12. On the relationships between apathy, depression and anhedonia.Journal of neurology, neurosurgery, and psychiatry · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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  19. Review
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Campbell Le HeronNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK campbell.leheron@ndcn.ox.ac.uk.
Clay B HolroydDepartment of Psychology, University of Victoria, Victoria, British Columbia, Canada.
John SalamoneDepartment of Psychological Sciences, University of Connecticut, Storrs, Connecticut, USA.
Masud HusainNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
John Radcliffe Hospital · GBUniversity of Connecticut · USUniversity of Oxford · GBUniversity of Victoria · CA

Funding

Wellcome TrustWellcome Trust 206330/Z/17/Z
6 · The paper itself

Abstract

The past few decades have seen growing interest in the neuropsychiatric syndrome of apathy, conceptualised as a loss of motivation manifesting as a reduction of goal-directed behaviour. Apathy occurs frequently, and with substantial impact on quality of life, in a broad range of neurological and psychiatric conditions. Apathy is also consistently associated with neuroimaging changes in specific medial frontal cortex and subcortical structures, suggesting that disruption of a common systems-level mechanism may underlie its development, irrespective of the condition that causes it. In parallel with this growing recognition of the clinical importance of apathy, significant advances have been made in understanding normal motivated behaviour in humans and animals. These developments have occurred at several different conceptual levels, from work linking neural structures and neuromodulatory systems to specific aspects of motivated behaviour, to higher order computational models that aim to unite these findings within frameworks for normal goal-directed behaviour. In this review we develop a conceptual framework for understanding pathological apathy based on this current understanding of normal motivated behaviour. We first introduce prominent theories of motivated behaviour-which often involves sequences of actions towards a goal that needs to be maintained across time. Next, we outline the behavioural effects of disrupting these processes in animal models, highlighting the specific effects of these manipulations on different components of motivated behaviour. Finally, we relate these findings to clinical apathy, demonstrating the homologies between this basic neuroscience work and emerging behavioural and physiological evidence from patient studies of this syndrome.

Indexed as

ApathyBrain DiseasesHumansMotivationapathycognitive neurosciencedecision makingeffortgoal-directed behaviourmotivationreward

Identifiers

PMID30366958
PMCPMC6518466
OpenAlexW2898202513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.