Evidence map›Paper›PMID 30366941›Full record

ArticleEMBO reports2018

BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in

Alessandro Torgovnick, Alfonso Schiavi, Anjumara Shaik, Henok Kassahun, Silvia Maglioni, Shane L Rea, Thomas E Johnson, Hans C Reinhardt, Sebastian Honnen, Björn Schumacher and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Alessandro TorgovnickLeibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany.
Alfonso SchiaviLeibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany.
Anjumara ShaikLeibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany.
Henok KassahunDepartment of Clinical Molecular Biology, University of Oslo, Oslo, Norway.
Silvia MaglioniLeibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany.
Shane L ReaDepartment of Pathology, University of Washington, Seattle, WA, USA.
Thomas E JohnsonInstitute for Behavioral Genetics & Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO, USA.
Hans C ReinhardtClinic I of Internal Medicine, Center for Integrated Oncology, Center for Molecular Medicine and the CECAD Research Center, University of Cologne, Cologne, Germany.
Sebastian HonnenMedical Faculty, Institute of Toxicology, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
Björn SchumacherMedical Faculty, Institute for Genome Stability in Aging and Disease, CECAD Research Center, University of Cologne, Cologne, Germany.ORCID 0000-0001-6097-5238
Hilde NilsenDepartment of Clinical Molecular Biology, University of Oslo, Oslo, Norway.
Natascia VenturaLeibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany natascia.ventura@uni-duesseldorf.de.ORCID 0000-0001-8718-4321
Leibniz Institute of Environmental Medicine · DEUniversity of Cologne · DEUniversity of Oslo · NOHeinrich Heine University Düsseldorf · DEUniversity of Colorado Boulder · USUniversity of Washington · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Interventions that promote healthy aging are typically associated with increased stress resistance. Paradoxically, reducing the activity of core biological processes such as mitochondrial or insulin metabolism promotes the expression of adaptive responses, which in turn increase animal longevity and resistance to stress. In this study, we investigated the relation between the extended

Indexed as

ApoptosisLongevityStress, PhysiologicalAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell ProliferationDNA DamageDNA RepairGerm CellsMitochondriaMitosisTumor Suppressor ProteinsUbiquitin-Protein LigasesBRC-1 protein, C elegansbrd-1 protein, C elegansCaenorhabditis elegans ProteinsTumor Suppressor ProteinsUbiquitin-Protein LigasesagingapoptosisBRC‐1/BRD‐1DNA damagemitochondria

Identifiers

PMID30366941
PMCPMC6280797
OpenAlexW2898184417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.