ArticleGenes & development2018
Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development.
Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Dynamics and master transcription factors dependence of intestinal super-enhancers during differentiation and oncogenesis.Nucleic acids research · 2026Article
- HAT1 Regulates Intestinal Stem Cell Proliferation and Differentiation.bioRxiv : the preprint server for biology · 2026Article
- Deep learning the dynamic regulatory sequence code of cardiac organoid differentiation.bioRxiv : the preprint server for biology · 2025Article
- A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin.Nature communications · 2024Article
- Tissue-location-specific transcription programs drive tumor dependencies in colon cancer.Nature communications · 2024Article
- DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation.Nature structural & molecular biology · 2024Article
- Invasive stratified mucin-producing carcinoma of the colorectum: expanding the morphologic spectrum of large bowel cancer.Diagnostic pathology · 2023Article
- Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation.Science advances · 2023Article
- An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate.Science advances · 2023Article
- Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation.Science advances · 2023Article
- Multiple roles and regulatory mechanisms of the transcription factor HNF4 in the intestine.Frontiers in endocrinology · 2023Review
- Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver.Cells · 2022Article
- Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions.Nature communications · 2022Article
- SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling.Cell stem cell · 2022Article
- Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer.Genes & development · 2022Article
- Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration.Developmental cell · 2021Article
- Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model.Nucleic acids research · 2021Article
- A Core Response to the CDX2 Homeoprotein During Development and in Pathologies.Frontiers in genetics · 2021Article
- Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium.Nature reviews. Gastroenterology & hepatology · 2021Review
- Epigenetic regulation of intestinal stem cell differentiation.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
After acquiring competence for selected cell fates, embryonic primordia may remain plastic for variable periods before tissue identity is irrevocably determined (commitment). We investigated the chromatin basis for these developmental milestones in mouse endoderm, a tissue with recognizable rostro-caudal patterning and transcription factor (TF)-dependent interim plasticity. Foregut-specific enhancers are as accessible and active in early midgut as in foregut endoderm, and intestinal enhancers and identity are established only after ectopic
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.