Evidence map›Paper›PMID 30366901›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2019

Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the

Tania E Perez Jimenez, Butch Kukanich, Hyun Joo, Katrina L Mealey, Tamara L Grubb, Stephen A Greene, Michael H Court

Open access · bronzeAbstract readClinical Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Dosing protocols to increase the efficacy of butorphanol in dogs.Journal of veterinary pharmacology and therapeutics · 2022
    Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tania E Perez JimenezProgram in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington (T.E.P.J., K.L.M., T.L.G., S.A.G., M.H.C.); and Department of Anatomy and Physiology, Institute of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Manhattan, Kansas (B.K., H.J.) teperezjimenez@wsu.edu.ORCID 0000-0002-5867-5276
Butch KukanichProgram in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington (T.E.P.J., K.L.M., T.L.G., S.A.G., M.H.C.); and Department of Anatomy and Physiology, Institute of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Manhattan, Kansas (B.K., H.J.).
Hyun JooProgram in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington (T.E.P.J., K.L.M., T.L.G., S.A.G., M.H.C.); and Department of Anatomy and Physiology, Institute of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Manhattan, Kansas (B.K., H.J.).
Katrina L MealeyProgram in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington (T.E.P.J., K.L.M., T.L.G., S.A.G., M.H.C.); and Department of Anatomy and Physiology, Institute of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Manhattan, Kansas (B.K., H.J.).
Tamara L GrubbProgram in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington (T.E.P.J., K.L.M., T.L.G., S.A.G., M.H.C.); and Department of Anatomy and Physiology, Institute of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Manhattan, Kansas (B.K., H.J.).
Stephen A GreeneProgram in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington (T.E.P.J., K.L.M., T.L.G., S.A.G., M.H.C.); and Department of Anatomy and Physiology, Institute of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Manhattan, Kansas (B.K., H.J.).
Michael H CourtProgram in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington (T.E.P.J., K.L.M., T.L.G., S.A.G., M.H.C.); and Department of Anatomy and Physiology, Institute of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Manhattan, Kansas (B.K., H.J.).
Kansas State University · US

Funding

MicroRNAs as effectors of variable human drug metabolismR01GM102130 · NIGMS · WASHINGTON STATE UNIVERSITY · PI COURT, MICHAEL H · 2012 to 2015
$1.1M
NIGMS NIH HHS R01 GM102130
6 · The paper itself

Abstract

Tramadol is used frequently in the management of mild to moderate pain conditions in dogs. This use is controversial because multiple reports in treated dogs demonstrate very low plasma concentrations of

Indexed as

Administration, OralAnalgesics, OpioidAnimalsCross-Over StudiesDogsDrug InteractionsFemaleFluconazoleMalePainRandom AllocationTramadolAnalgesics, OpioidFluconazoleN-demethyltramadolO-demethyltramadolTramadol

Identifiers

PMID30366901
PMCPMC6290082
OpenAlexW2898141042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.