ArticleInternational journal of cardiology2019
Aortic arch tortuosity, a novel biomarker for thoracic aortic disease, is increased in adults with bicuspid aortic valve.
Article in International journal of cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Analysis of Morphological High-Risk Factors for Retrograde Type A Aortic Dissection.Reviews in cardiovascular medicine · 2026Article
- Effects of vessel morphology on aortic hemodynamics: a statistical shape and CFD investigation.Medical & biological engineering & computing · 2026Article
- Emerging imaging and circulating biomarkers in relation to underlying mechanisms in Bicuspid Aortic Valve aortopathy.International journal of cardiology. Heart & vasculature · 2025Review
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Clinical value of aortic arch morphology in transfemoral TAVR: artificial intelligence evaluation.International journal of surgery (London, England) · 2025Article
- 3D Characterization of the Aortic Valve and Aortic Arch in Bicuspid Aortic Valve Patients.Annals of biomedical engineering · 2024Article
- Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension.Orphanet journal of rare diseases · 2024Article
- Transcarotid vascular access for transcatheter aortic valve implantation: is choosing the left side always right?Journal of cardiothoracic surgery · 2024Article
- The geometric evolution of aortic dissections: Predicting surgical success using fluctuations in integrated Gaussian curvature.PLoS computational biology · 2024Article
- Development of idealized human aortic models forFrontiers in cardiovascular medicine · 2024Article
- Stiffness matters: Improved failure risk assessment of ascending thoracic aortic aneurysms.JTCVS open · 2023Article
- Navigating the challenges of bicuspid aortic valve-aortopathy.Global cardiology science & practice · 2023Review
- The Role of Spatial Aortic Arch Architecture in Type B Aortic Dissection.Journal of clinical medicine · 2023Article
- Using computed tomography angiography and computational fluid dynamics to study aortic coarctation in different arch morphologies.Frontiers in pediatrics · 2023Article
- Relationship Between Length and Curvature of Ascending Aorta and Type a Dissection.Frontiers in cardiovascular medicine · 2022Article
- Treatment of Bicuspid Aortic Valve Stenosis with TAVR: Filling Knowledge Gaps Towards Reducing Complications.Current cardiology reports · 2022Review
- Morphological Features of Aortic Arch Predicting the Risk for Acute Type B Aortic Dissection.World journal of surgery · 2021Article
- Prescreening and treatment of aortic dissection through an analysis of infinite-dimension data.BioData mining · 2021Article
- Bayesian Estimation of Geometric Morphometric Landmarks for Simultaneous Localization of Multiple Anatomies in Cardiac CT Images.Entropy (Basel, Switzerland) · 2021Article
- Aortic Geometric Alteration Associated With Acute Type B Aortic Dissection: Angulation, Tortuosity, and Arch Type.Frontiers in physiology · 2021Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionArterial tortuosity has emerged as a predictor of adverse outcomes in congenital aortopathies using 3D reconstructed images. We validated a new method to estimate aortic arch tortuosity on 2D CT. We hypothesize that arch tortuosity may identify bicuspid aortic valve (BAV) patients at high risk to develop thoracic aortic aneurysms or aortic dissections (TAD).
methodsBAV subjects with chest CT scans were retrospectively identified in our clinical records and matched to tricuspid aortic valve (TAV) controls by age, gender, and presentation with TAD. Subjects with prior ascending aortic intervention were excluded. Measurements included aortic arch tortuosity, length, angle, width and height. Total aortic tortuosity was estimated in subjects with available abdominal images.
results120 BAV and 234 TAV subjects were included. Our 2D measurements were highly correlated with 3D midline arch measurements and had high inter- and intra-observer reliability. Compared to TAV, BAV subjects had increased arch tortuosity (median 1.76 [Q1-Q3: 1.62-1.95] vs. 1.63 [1.53-1.78], P < 0.01), length (149 [136-160] vs. 135 [122-152] mm, P < 0.01), height (46 [41-53] vs. 39 [34-47] mm, P < 0.01), and vertex acuity (70 [61-77] vs. 75 [68-81] degree, P < 0.01). In a multivariable analysis, arch tortuosity remained independently associated with BAV after adjusting for aortic diameter and other clinical characteristics.
conclusionsWe found that aortic arch tortuosity is significantly increased in BAV and may identify BAV patients who are at increased risk for TAD. Further studies to evaluate the association between tortuosity and clinical outcomes are in progress.
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