ArticleImmunity2018
T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.
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Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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0cells of the map it votes in
19citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
What it found
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Unconventional role of hydroxymethylglutaryl-CoA synthase 1 in driving pathogenic TScience advances · 2026Article
- Interferon-β Coordinates Epithelial Immune Networks and Fibrotic Responses DuringbioRxiv : the preprint server for biology · 2026Article
- Resolving the field: a role for Nod2 in T cells.Journal of immunology (Baltimore, Md. : 1950) · 2025Review
- Single-cell transcriptomics uncovers key immune drivers of vaccine efficacy in cattle.BMC genomics · 2025Article
- Article
- Current advances on RIPK2 and its inhibitors in pathological processes: a comprehensive review.Frontiers in molecular neuroscience · 2025Review
- In vitro silencing of RIP2 in naive CD4Clinical rheumatology · 2024Article
- TIM-4 Identifies Effector B Cells Expressing a RORγt-Driven Proinflammatory Cytokine Module That Promotes Immune Responsiveness.bioRxiv : the preprint server for biology · 2024Article
- "RIPping" off Pancreas Cancer's Blockage of Immune Surveillance.Cancer discovery · 2024Article
- Emerging Role of Dendritic Cell Intervention in the Treatment of Inflammatory Bowel Disease.BioMed research international · 2022Review
- Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media.Frontiers in genetics · 2022Article
- Research progress on Th17 and T regulatory cells and their cytokines in regulating atherosclerosis.Frontiers in cardiovascular medicine · 2022Review
- Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TNature communications · 2021Article
- RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases.Frontiers in pharmacology · 2021Review
- Immune Modulation of Allergic Asthma by Early Pharmacological Inhibition of RIP2.ImmunoHorizons · 2020Article
- Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.The Journal of experimental medicine · 2020Article
- Molecular control of pathogenic Th17 cells in autoimmune diseases.International immunopharmacology · 2020Review
- RICK/RIP2 is a NOD2-independent nodal point of gut inflammation.International immunology · 2019Article
- RIP2 promotes FcγR-mediated reactive oxygen species production.The Journal of biological chemistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Kenichi ShimadaDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Infectious and Immunologic Disease Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Science, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Rebecca A PorrittDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Janet L MarkmanDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jacqueline Gire O'RourkeBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Daiko WakitaDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Magali Noval RivasDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Infectious and Immunologic Disease Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Science, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Chihiro OgawaF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Lina KozhayaThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Gislâine A MartinsDepartment of Biomedical Science, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Derya UnutmazThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Robert H BalohBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Timothy R CrotherDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Infectious and Immunologic Disease Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Science, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Shuang ChenDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Infectious and Immunologic Disease Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Science, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Moshe ArditiDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Infectious and Immunologic Disease Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Science, Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: moshe.arditi@cshs.org.
Cedars-Sinai Medical Center · USJackson Laboratory · USUniversity of California, Los Angeles · US
Funding
Role of Blimp1 (Prdm1) in lung immune responses and toleranceR01AI103542 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI MARTINS, GISLAINE A · 2013 to 2025
$4.6MInteraction with Rip2 and Th17 in Chronic InflammationR01AI117968 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2016 to 2020
$2.3MInnate Immunity and Pathogen mediated Acceleration in Vascular InflammationR01HL111483 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHEN, SHUANG · 2012 to 2016
$2.0MRole of C9orf72 in NeurodegenerationR01NS097545 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI BALOH, ROBERT · 2016 to 2020
$2.0MRole of Innate Immunity in Pathogenesis of Chlamydia Pneumonia InfectionR01AI067995 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2006 to 2010
$1.9MThe role of the inflammasome in plasmacytoid dendritic cells during bacterial infectionR21AI112826 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI CROTHER, TIMOTHY ROBERT · 2015 to 2016
$481kInteraction with Rip2 and Th17 in Chronic InflammationR56AI117968 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2015 to 2015
$438kInnate Immunity and Host Responses in Pathogenesis of Chlamydia PneumoniaeR56AI067995 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2012 to 2012
$413kAmerican Heart Association-American Stroke Association 09BGIA2060145NHLBI NIH HHS R01 HL111483NIAID NIH HHS R01 AI067995NIAID NIH HHS R01 AI103542NIAID NIH HHS R01 AI117968NIAID NIH HHS R21 AI112826NIAID NIH HHS R56 AI067995NIAID NIH HHS R56 AI117968NINDS NIH HHS R01 NS097545
Abstract
Receptor interacting protein 2 (RIP2) plays a role in sensing intracellular pathogens, but its function in T cells is unclear. We show that RIP2 deficiency in CD4
Indexed as
AnimalsAtherosclerosisBiomarkersCaspase Activation and Recruitment DomainCell DifferentiationEncephalomyelitis, Autoimmune, ExperimentalGene ExpressionImmunophenotypingInflammationInterleukin-17Interleukin-1betaMiceMice, KnockoutNuclear Receptor Subfamily 1, Group F, Member 1Receptor-Interacting Protein Serine-Threonine Kinase 2Receptor-Interacting Protein Serine-Threonine KinasesBiomarkersIL1B protein, mouseInterleukin-17Interleukin-1betaNuclear Receptor Subfamily 1, Group F, Member 1Receptor-Interacting Protein Serine-Threonine Kinase 2Receptor-Interacting Protein Serine-Threonine KinasesRipk2 protein, mouseRora protein, mouseatherosclerosisChlamydia pneumoniaechronic inflammationIL-17RIP2RORαTh17
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.