Evidence map›Paper›PMID 30366389›Full record

ArticleMarine drugs2018

Excavatolide-B Enhances Contextual Memory Retrieval via Repressing the Delayed Rectifier Potassium Current in the Hippocampus.

Irene Y Huang, Yu-Luan Hsu, Chien-Chang Chen, Mei-Fang Chen, Zhi-Hong Wen, Hsien-Ting Huang, Ingrid Y Liu

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Activation of GABA transmission by clonazepam reverses the autistic-like phenotypes of the Cav3.2 knockout mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  2. [Effects ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Irene Y HuangDepartment of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan. yuchunirene@gate.sinica.edu.tw.
Yu-Luan HsuDepartment of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan. to745812@gmail.com.ORCID 0000-0002-4565-4222
Chien-Chang ChenInstitute of Biomedical Sciences, Academia Sinica, 128, Academia road, Section 2, Nangang, Taipei 115, Taiwan. ccchen@ibms.sinica.edu.tw.
Mei-Fang ChenCardiovascular and Metabolomics Research Center, Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan. mfchen@mail.tcu.edu.tw.
Zhi-Hong WenDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
Hsien-Ting HuangDepartment of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan. hsia94@gms.tcu.edu.tw.
Ingrid Y LiuDepartment of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan. ycliu@gms.tcu.edu.tw.ORCID 0000-0002-2795-2461
Tzu Chi University · TWBuddhist Tzu Chi General Hospital · TWInstitute of Biomedical Sciences, Academia Sinica · TWNational Sun Yat-sen University · TW

Funding

Ministry of Science and Technology, Taiwan NSC 99-2323-B-291-001Tzu Chi University/Tzu Chi Foundation TCRPP105013
6 · The paper itself

Abstract

Memory retrieval dysfunction is a symptom of schizophrenia, autism spectrum disorder (ASD), and absence epilepsy (AE), as well as an early sign of Alzheimer's disease. To date, few drugs have been reported to enhance memory retrieval. Here, we found that a coral-derived natural product, excavatolide-B (Exc-B), enhances contextual memory retrieval in both wild-type and

Indexed as

AnimalsBehavior, AnimalCalcium Channels, T-TypeConditioning, PsychologicalDelayed Rectifier Potassium ChannelsDendritic SpinesDiterpenesFearHippocampusLong-Term PotentiationMaleMemoryMiceMice, Inbred C57BLMice, KnockoutPrimary Cell CultureCacna1h protein, mouseCalcium Channels, T-TypeDelayed Rectifier Potassium ChannelsDiterpenesexcavatolide Babsence epilepsyautism spectrum disorderCav3.2−/− micecoralexcavatolide-Blong-term potentiationmemorypotassium currentT-type calcium channel

Identifiers

PMID30366389
PMCPMC6266063
OpenAlexW2898460836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.