ArticleJournal of clinical medicine2018
Low Blood ALT Activity and High FRAIL Questionnaire Scores Correlate with Increased Mortality and with Each Other. A Prospective Study in the Internal Medicine Department.
Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Serum ALT activity and its isoenzymes as potential biomarkers for diagnosis of Sarcopenia in older adults: a retrospective, cross-sectional study.BMC geriatrics · 2025Article
- Low ALT levels and a new diagnosis of congestive heart failure following COVID-19 infection.Frontiers in cardiovascular medicine · 2025Article
- Comorbid Hypothyroidism and Low-Alanine Aminotransferase-Associated Sarcopenia Associated with Shortened Survival: A Retrospective Study of 16,827 Patients over a 21-Year Period.Journal of clinical medicine · 2024Article
- Low ALT Is Associated with IBD and Disease Activity: Results from a Nationwide Study.Journal of clinical medicine · 2024Article
- Physical Interventions Restore Physical Frailty and the Expression of CXCL-10 and IL-1β Inflammatory Biomarkers in Old Individuals and Mice.Biomolecules · 2024Article
- Dynamic chronological changes of upper reference limits for liver enzymes in the nationwide population: the Korean National Health Insurance Service-National Sample Cohort 2002-2013.Archives of medical science : AMS · 2024Article
- Association of AST/ALT (De Ritis) ratio with sarcopenia in a Chinese population of community-dwelling elderly.Heliyon · 2023Article
- Do low levels of alanine aminotransferase, a baseline marker of sarcopenia and frailty, associate with worse clinical outcomes among hospitalized COVID-19 patients? A Retrospective Cohort Study.Journal of frailty, sarcopenia and falls · 2023Article
- Use of frailty assessment instruments in nephrology populations: a scoping review.BMC geriatrics · 2023Article
- The Association between Liver Enzymes and Mortality Stratified by Non-Alcoholic Fatty Liver Disease: An Analysis of NHANES III.Nutrients · 2023Article
- Prevalence and outcomes of frailty in unplanned hospital admissions: a systematic review and meta-analysis of hospital-wide and general (internal) medicine cohorts.EClinicalMedicine · 2023Article
- Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome.Medicina (Kaunas, Lithuania) · 2023Article
- Patients with low ALT levels are at increased risk for severe COVID-19.Frontiers in medicine · 2023Article
- Circulating liver function markers and the risk of COPD in the UK Biobank.Frontiers in endocrinology · 2023Article
- Sarcopenia and Frailty in Heart Failure: Is There a Biomarker Signature?Current heart failure reports · 2022Review
- Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study.BMC gastroenterology · 2022Article
- Frailty Status Improvement after 5-Month Multicomponent Program PROMUFRA in Community-Dwelling Older People: A Randomized Controlled Trial.Journal of clinical medicine · 2022Article
- Low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males.Scientific reports · 2021Observational
- Comparison of three frailty measures for 90-day outcomes of elderly patients undergoing elective abdominal surgery.ANZ journal of surgery · 2021Article
- Low ALT Levels Associated with Poor Outcomes in 8700 Hospitalized Heart Failure Patients.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow blood ALT, Alanine aminotransferase activity and high FRAIL (Fatigue, Resistance, Ambulation, Illnesses and Loss of Weight) questionnaire scores were previously shown to be associated with frailty and increased risk of mortality. We aimed to correlate these tools with mortality and each other in patients hospitalized in an internal medicine department.
methodsThis is a prospective study in a large tertiary hospital. We assessed the predictive value for clinical outcomes of both low ALT blood activity and the pre-frail and frail categories of the "FRAIL" questionnaire.
resultsDuring a 15 months study, 179 consecutive patients were recruited, of whom 20 died. When all study participants were divided to three groups according to admission ALT levels (below 10 IU/L, 11 to 19 IU/L and above 20 IU/L) we found a statistically significant difference in the rate of mortality: 4 patients died within the group of ALT < 10 IU/L, 14 patients died in the group of 10 IU/L < ALT < 19 IU/L and in the group of patients with ALT > 20 IU/L, only 2 patients died (
conclusionsBoth the FRAIL questionnaire and blood ALT activity are simple and practical tools for frailty assessment and risk stratification of patients hospitalized in the internal medicine department. Both tool's results also correlate with each other.
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