ArticleMolecules (Basel, Switzerland)2018
Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Study and application of graphene oxide in the synthesis of 2,3-disubstituted quinolinesRSC advances · 2022Article
- An approach to new chiral bicyclic imines and aminesRSC advances · 2020Article
- Multicomponent Reactions.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
5 authors.
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Abstract
Tetrazoles have been widely studied for their biological properties. An efficient route for large-scale synthesis of 1,5-disubstituted tetrazoles (1,5-DTs) is presented. The strategy exploits a reductive approach to synthetize a cyclic chiral imine substrate which is then converted into the target product through an Ugi-azide three-component reaction (UA-3CR). The final products are equipped with additional functionalities which can be further elaborated for the generation of combinatorial libraries of enantiopure heterocycles.
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Registered trials
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