Evidence map›Paper›PMID 30366205›Full record

ArticleJournal of neuroimmunology2018

Distinct roles for Blimp-1 in autoreactive CD4 T cells during priming and effector phase of autoimmune encephalomyelitis.

Saba I Aqel, Marissa C Granitto, Patrick K Nuro-Gyina, Wei Pei, Yue Liu, Amy E Lovett-Racke, Michael K Racke, Yuhong Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Saba I AqelDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: aqel.3@buckeyemail.osu.edu.
Marissa C GranittoNeuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH 43210, USA. Electronic address: granitto.4@buckeyemail.osu.edu.
Patrick K Nuro-GyinaPostbacculaureate Research Education Program, The Ohio State University, Columbus, OH 43210, USA.
Wei PeiDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: wei.pei@osumc.edu.
Yue LiuDepartment of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: Liu.606@osu.edu.
Amy E Lovett-RackeDepartment of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: amy.lovett-racke@osumc.edu.
Michael K RackeDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: michael.racke@osumc.edu.
Yuhong YangDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: yuhong.yang@osumc.edu.
The Ohio State University Wexner Medical Center · USThe Ohio State University · US

Funding

Small molecule in vivo probe development targeting the IL-6/STAT3 pathway for potential multiple sclerosis therapyR01NS088437 · NINDS · UNIVERSITY OF FLORIDA · PI LI, CHENGLONG, YANG, YUHONG · 2015 to 2017
$1.3M
NINDS NIH HHS R01 NS088437
6 · The paper itself

Abstract

B lymphocyte-induced maturation protein (Blimp-1) is a transcription factor that regulates effector/memory B cells and CD8 T cells. Here we show that Blimp-1 is expressed in both Th1 and Th17 cells in vitro and highly expressed in effector/memory myelin-specific CD4 T cells in experimental autoimmune encephalomyelitis (EAE) mice. The immunized Blimp-1 conditional knockout mice have a significantly delayed disease onset but enhanced disease severity during the effector phase compared to their wild-type littermates, suggesting that Blimp-1 is a unique transcription factor with distinct roles in the regulation of myelin-specific CD4 T cells during priming and effector phase of EAE.

Indexed as

AnimalsCD4-Positive T-LymphocytesCells, CulturedEncephalomyelitis, Autoimmune, ExperimentalMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPositive Regulatory Domain I-Binding Factor 1Positive Regulatory Domain I-Binding Factor 1Prdm1 protein, mouseB lymphocyte-induced maturation protein (Blimp-1)experimental autoimmune encephalomyelitis (EAE)Multiple Sclerosis (MS)Th1Th17

Identifiers

PMID30366205
PMCPMC6258060
OpenAlexW2898011656

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.