ReviewBrain research2019
Thalamic inhibitory circuits and network activity development.
Review in Brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Sleep spindle density increases in patients with severe obstructive sleep apnea after 6 months of treatment: a longitudinal study.Scientific reports · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The ventrolateral preoptic nucleus: a multisystem integrator in sleep-wake regulation.Frontiers in neuroscience · 2026Review
- When the gatekeeper falls: developmental vulnerability of the thalamic reticular nucleus in neonatal and pediatric hypoxic-ischemic brain injury.Frontiers in systems neuroscience · 2026Review
- A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice.Nature communications · 2025Article
- Dysfunction of the rostral lateral septum GABAergic neurons induces mania-like behavior in male mice.Translational psychiatry · 2025Article
- Generalized Slowing of Resting-State Neural Oscillations in People With Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy.PLoS computational biology · 2025Article
- Quantitative electroencephalography in the diagnosis of dementia with Lewy bodies.Clinical neurophysiology practice · 2025Review
- Structure of subcortico-cortical tracts in middle-aged and older adults with autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Development of reciprocal connections between the dorsal lateral geniculate nucleus and the thalamic reticular nucleus.Neural development · 2024Article
- Coincident development and synchronization of sleep-dependent delta in the cortex and medulla.Current biology : CB · 2024Article
- DELTA-RHYTHMIC ACTIVITY IN THE MEDULLA DEVELOPS COINCIDENT WITH CORTICAL DELTA IN SLEEPING INFANT RATS.bioRxiv : the preprint server for biology · 2024Article
- A Thalamocortical Perspective on Sleep Spindle Alterations in Neurodevelopmental Disorders.Current sleep medicine reports · 2024Review
- FGF3 Directs the Pathfinding of Prethalamic GABAergic Axons.International journal of molecular sciences · 2023Article
- A phylogenetically-conserved axis of thalamocortical connectivity in the human brain.Nature communications · 2023Article
- Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition.Cell reports · 2023Article
- Article
- Sleep, plasticity, and sensory neurodevelopment.Neuron · 2022Review
- Postnatal development of thalamic reticular nucleus projections to the anterior thalamic nuclei in rats.European journal of histochemistry : EJH · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Inhibitory circuits in thalamus and cortex shape the major activity patterns observed by electroencephalogram (EEG) in the adult brain. Their delayed maturation and circuit integration, relative to excitatory neurons, suggest inhibitory neuronal development could be responsible for the onset of mature thalamocortical activity. Indeed, the immature brain lacks many inhibition-dependent activity patterns, such as slow-waves, delta oscillations and sleep-spindles, and instead expresses other unique oscillatory activities in multiple species including humans. Thalamus contributes significantly to the generation of these early oscillations. Compared to the abundance of studies on the development of inhibition in cortex, however, the maturation of thalamic inhibition is poorly understood. Here we review developmental changes in the neuronal and circuit properties of the thalamic relay and its interconnected inhibitory thalamic reticular nucleus (TRN) both in vitro and in vivo, and discuss their potential contribution to early network activity and its maturation. While much is unknown, we argue that weak inhibitory function in the developing thalamus allows for amplification of thalamocortical activity that supports the generation of early oscillations. The available evidence suggests that the developmental acquisition of critical thalamic oscillations such as slow-waves and sleep-spindles is driven by maturation of the TRN. Further studies to elucidate thalamic GABAergic circuit formation in relation to thalamocortical network function would help us better understand normal as well as pathological brain development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.