ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Component mechanisms of executive function in schizophrenia and their contribution to functional outcomes.
Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Scrutinizing Domains of Executive Function in Binge Eating Disorder: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2020Pooled it
- Article
- Characterizing executive dysfunctions in patients with schizo-obsessive comorbidity: comparing schizophrenia with obsessive-compulsive disorder.Psychological medicine · 2026Article
- Differential patterns of executive dysfunction across depressive phenotype in schizophrenia and major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Are Executive Functions Deficits in Early-Onset Chronic Schizophrenia More Severe than in Adult-Onset Chronic Schizophrenia?Clinical neuropsychiatry · 2022Article
- A Short Version of the EFECO Online Questionnaire for the Assessment of Executive Functions in School-Age Children.Children (Basel, Switzerland) · 2021Article
- Rethinking the effects of working memory training on executive functions in schizophrenia: A machine learning approach.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
7 authors.
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Abstract
objectiveIn schizophrenia, scores reflecting deficits in different cognitive processes are strongly correlated, making it difficult to establish a solid relationship between different cognitive mechanisms and other features of this disorder. The objective of this study was to explore whether three frequently postulated executive functions (updating, shifting, and inhibition) could be compared between groups and considered independently in terms of their respective roles in functional outcome.
methodsThis study relied on confirmatory factor analysis of schizophrenia patients (n=141) and healthy controls (n=119). The main analyses examined the degree to which three executive functions (updating, set-shifting, and inhibition) could be separated in schizophrenia and compared this model among groups. Structural equation modeling analysis was also performed to examine the extent to which executive function components contribute to functional outcome in schizophrenia.
resultsMultiple-group confirmatory factor analysis with unconstrained model parameters indicated that the full three-factor model may fit the data in both groups (χ2 = 61.48, degrees of freedom = 34, p < 0.001, comparative fit index = 0.95; standardized root mean square residual = 0.037; root mean square error of approximation = 0.04; Akaike's information criteria = 169.49; normed fit index = 0.90), although there was also a good data fit for the patient group with a two-factor model. In the patient group, structural equation modeling suggested that shifting and (principally) updating were associated with the general measure of functional outcome (regression path coefficients: 0.34, p < 0.005; 0.39, p < 0.005, respectively), although when combined the mechanisms fail to contribute.
conclusionThis data suggests that the factor structure may be similar but not identical between groups, and both updating and shifting may play an important role in functional outcome in schizophrenia.
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