ArticlePloS one2018
Phenotypic characterization and whole genome analysis of extended-spectrum beta-lactamase-producing bacteria isolated from dogs in Germany.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transmission routes of antibiotic resistant bacteria: a systematic review.BMC infectious diseases · 2022Pooled it
- Genotypic characterization of extended-spectrum beta-lactamase-producingMicrobiology spectrum · 2025Article
- Sublethal concentrations of antibiotics enhance transmission of antibiotic resistance genes in environmentalFrontiers in microbiology · 2025Article
- First Report and Characterization of a Plasmid-EncodedMicroorganisms · 2024Article
- Microbiological Survey and Evaluation of Antimicrobial Susceptibility Patterns of Microorganisms Obtained from Suspect Cases of Canine Otitis Externa in Gran Canaria, Spain.Animals : an open access journal from MDPI · 2024Article
- Prevalence and antimicrobial resistance of Enterobacteriaceae in the north of Kazakhstan.Open veterinary journal · 2024Article
- Tad pili contribute to the virulence and biofilm formation of virulentFrontiers in cellular and infection microbiology · 2024Article
- Isolation and genotypic characterization of extended-spectrum beta-lactamase-producing Escherichia coli O157:H7 and Aeromonas hydrophila from selected freshwater sources in Southwest Nigeria.Scientific reports · 2023Article
- Phenotypic Characterization and Antibiograms of Extended-Spectrum Beta-Lactamase-ProducingInfection and drug resistance · 2023Article
- Characterization of cephalosporin and fluoroquinolone resistant Enterobacterales from Irish farm waste by whole genome sequencing.Frontiers in microbiology · 2023Article
- Fecal shedding of extended-spectrum beta-lactamase-producing Enterobacterales in cats admitted to an animal shelter.Journal of feline medicine and surgery · 2022Article
- Antimicrobial Resistance Genes and Diversity of Clones among Faecal ESBL-ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Comparative genomic analysis ofMicrobial genomics · 2021Article
- Global prevalence and molecular characterization of extended-spectrum β-lactamase producing-One health (Amsterdam, Netherlands) · 2021Article
- High β-lactam resistance in Gram-negative bacteria associated with kennel cough and cat flu in Egypt.Scientific reports · 2021Article
- Exploring the Antibiotic Resistance Burden in Livestock, Livestock Handlers and Their Non-Livestock Handling Contacts: A One Health Perspective.Frontiers in microbiology · 2021Article
- Article
- Molecular Characteristics of Extraintestinal PathogenicMicroorganisms · 2020Article
- Broad-Spectrum Cephalosporin-Resistant and/or Fluoroquinolone-ResistantAntibiotics (Basel, Switzerland) · 2020Article
- Genomic Characterisation of a Multiple Drug Resistant IncHI2 ST4 Plasmid inMicroorganisms · 2020Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asymptomatic colonization with extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae has been described for humans, various mammal species, and birds. Here, antimicrobial resistant bacteria were recovered from dog feces originating in Germany, Kosovo, Afghanistan, Croatia, and Ukraine, with a subset of mostly E. coli isolates obtained from a longitudinal collection over twelve months. In vitro antimicrobial resistance testing revealed various patterns of resistance against single or all investigated beta-lactam antibiotics, with none of the 101 isolates resistant against two tested carbapenem antibiotics. Whole genome sequence analysis revealed bacteria species-specific patterns for 23 antimicrobial resistance coding DNA sequences (CDS) that were unapparent from the in vitro analysis alone. Phylogenetic analysis of single nucleotide polymorphisms (SNP) revealed clonal bacterial isolates originating from different dogs, suggesting transmission between dogs in the same community. However, individual resistant E. coli clones were not detected over a period longer than seven days. Multi locus sequence typing (MLST) of 85 E. coli isolates revealed 31 different sequence types (ST) with an accumulation of ST744 (n = 9), ST10 (n = 8), and ST648 (n = 6), although the world-wide hospital-associated CTX-M beta-lactamase producing ST131 was not detected. Neither the antimicrobial resistance CDSs patterns nor the phylogenetic analysis revealed an epidemiological correlation among the longitudinal isolates collected from a period longer than seven days. No genetic linkage could be associated with the geographic origin of isolates. In conclusion, healthy dogs frequently carry ESBL-producing bacteria, independent to prior treatment, which may be transmitted between individual dogs of the same community. Otherwise, these antimicrobial resistant bacteria share few commonalities, making their presence eerily unpredictable.
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