ArticleBiochemistry2018
Characterization of Natural Colibactin-Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening.
Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Prostate Cancer at the Microbial Crossroads: Illuminating a New Frontier in Precision Medicine.The world journal of men's health · 2026Review
- Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.Natural product reports · 2026Review
- Synthesis and Biological Evaluation of Colibactin Derivatives.ACS chemical biology · 2026Article
- The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin.Science (New York, N.Y.) · 2025Article
- The specificity and structure of DNA crosslinking by the gut bacterial genotoxin colibactin.bioRxiv : the preprint server for biology · 2025Article
- Bacterial small molecule metabolites implicated in gastrointestinal cancer development.Nature reviews. Microbiology · 2025Review
- Article
- Structure Elucidation of Secondary Metabolites: Current Frontiers and Lingering Pitfalls.Accounts of chemical research · 2023Article
- Delivery, structure, and function of bacterial genotoxins.Virulence · 2022Review
- Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites.Science (New York, N.Y.) · 2022Article
- Evolution of Polymyxin Resistance Regulates Colibactin Production inACS chemical biology · 2021Article
- Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.Nature communications · 2021Article
- The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin.mSphere · 2020Article
- Employing chemical synthesis to study the structure and function of colibactin, a "dark matter" metabolite.Natural product reports · 2020Review
- Structure and bioactivity of colibactin.Bioorganic & medicinal chemistry letters · 2020Review
- Depurination of Colibactin-Derived Interstrand Cross-Links.Biochemistry · 2020Article
- The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin.mSphere · 2019Article
- The mysteries of macrocyclic colibactins.Nature chemistry · 2019Article
- Synthesis and reactivity of precolibactin 886.Nature chemistry · 2019Article
- Structure elucidation of colibactin and its DNA cross-links.Science (New York, N.Y.) · 2019Article
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5 authors.
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Abstract
Colibactins are genotoxic secondary metabolites whose biosynthesis is encoded in the clb gene cluster harbored by certain strains of gut commensal Escherichia coli. Using synthetic colibactin analogues, we previously provided evidence that colibactins alkylate DNA by addition of a nucleotide to an electrophilic cyclopropane intermediate. However, natural colibactin-nucleobase adducts have not been identified, to the best of our knowledge. Here we present the first identification of such adducts, derived from treatment of pUC19 DNA with clb
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