Evidence map›Paper›PMID 30365177›Full record

ArticleEuropean journal of immunology2019

IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation.

Diana C Yánez, Hemant Sahni, Susan Ross, Anisha Solanki, Ching-In Lau, Eleftheria Papaioannou, Alessandro Barbarulo, Rebecca Powell, Ulrike C Lange, David J Adams and 5 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
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  5. Review
  6. Review
  7. Review
  8. Article
  9. mBio · 2025
    Review
  10. Article
  11. IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Diana C YánezUCL Great Ormond Street Institute of Child Health, London, UK.
Hemant SahniUCL Great Ormond Street Institute of Child Health, London, UK.
Susan RossUCL Great Ormond Street Institute of Child Health, London, UK.
Anisha SolankiUCL Great Ormond Street Institute of Child Health, London, UK.
Ching-In LauUCL Great Ormond Street Institute of Child Health, London, UK.
Eleftheria PapaioannouUCL Great Ormond Street Institute of Child Health, London, UK.
Alessandro BarbaruloUCL Great Ormond Street Institute of Child Health, London, UK.
Rebecca PowellUCL Great Ormond Street Institute of Child Health, London, UK.
Ulrike C LangeDepartment of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
David J AdamsWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Martino BarencoUCL Great Ormond Street Institute of Child Health, London, UK.
Masahiro OnoUCL Great Ormond Street Institute of Child Health, London, UK.
Fulvio D'AcquistoHealth Science Research Centre, University of Roehampton, London, UK.
Anna L FurmanskiUCL Great Ormond Street Institute of Child Health, London, UK.
Tessa CromptonUCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-8973-4021
Great Ormond Street Hospital · GBUniversität Hamburg · DEUniversity of Bedfordshire · GBUniversity of Roehampton · GBWellcome Sanger Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/1026324/1Medical Research Council MR/P000843/1
6 · The paper itself

Abstract

The interferon-inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4

Indexed as

AnimalsCell DifferentiationCells, CulturedHypersensitivityInflammationInterferon-gammaInterleukin-27Interleukin-4Lymphocyte ActivationMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutRespiratory SystemTh1 CellsTh1-Th2 Balancefragilis3 protein, mousefragilis protein, mouseInterferon-gammaInterleukin-27Interleukin-4Membrane ProteinsAllergic airway diseaseIFN-γInterferon-inducible transmembrane (IFITM) proteinT helper 1 (Th1)T helper 2 (Th2)

Identifiers

PMID30365177
PMCPMC6396086
OpenAlexW2898471127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.