Semiparametric Bayesian latent variable regression for skewed multivariate data.

For many real-life studies with skewed multivariate responses, the level of skewness and association structure assumptions are essential for evaluating the covariate effects on the response and its predictive distribution. We present a novel semiparametric multivariate model and associated Bayesian analysis for multivariate skewed responses. Similar to multivariate Gaussian densities, this multivariate model is closed under marginalization, allows a wide class of multivariate associations, and has meaningful physical interpretations of skewness levels and covariate effects on the marginal density. Other desirable properties of our model include the Markov Chain Monte Carlo computation through available statistical software, and the assurance of consistent Bayesian estimates of the parameters and the nonparametric error density under a set of plausible prior assumptions. We illustrate the practical advantages of our methods over existing alternatives via simulation studies and the analysis of a clinical study on periodontal disease.