ArticleInternational journal of molecular medicine2019
MicroRNA-421-targeted PDCD4 regulates breast cancer cell proliferation.
Article in International journal of molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Apoptotic Signaling Across Breast Cancer Subtypes and Cryoablation-Induced Tissue Injury.International journal of molecular sciences · 2026Article
- m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.NPJ precision oncology · 2025Article
- Identification and validation of miR-583 and mir-877-5p as biomarkers in patients with breast cancer: an integrated experimental and bioinformatics research.BMC research notes · 2023Article
- Circulating microRNA Biomarker for Detecting Breast Cancer in High-Risk Benign Breast Tumors.International journal of molecular sciences · 2023Article
- Human Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miRNA-21-5p Inhibits Lidocaine-Induced Apoptosis in SH-SY5Y Neuroblastoma Cells.Iranian journal of public health · 2023Article
- Integration of TE Induces Cancer Specific Alternative Splicing Events.International journal of molecular sciences · 2022Review
- Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases.International journal of molecular sciences · 2022Review
- CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases.Frontiers in genetics · 2022Review
- Dissecting the Roles of PDCD4 in Breast Cancer.Frontiers in oncology · 2022Review
- Interplay Between Non-Coding RNAs and Programmed Cell Death Proteins.Frontiers in oncology · 2022Review
- circ_0000567/miR-421/Journal of Cancer · 2022Article
- Long Noncoding RNA GAS5 in Breast Cancer: Epigenetic Mechanisms and Biological Functions.International journal of molecular sciences · 2021Review
- Circ_0003266 sponges miR-503-5p to suppress colorectal cancer progression via regulating PDCD4 expression.BMC cancer · 2021Observational
- Article
- Genomic instability-derived plasma extracellular vesicle-microRNA signature as a minimally invasive predictor of risk and unfavorable prognosis in breast cancer.Journal of nanobiotechnology · 2021Article
- Article
- Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer.Non-coding RNA · 2020Review
- Targeting of KDM5A by miR-421 in Human Ovarian Cancer Suppresses the Progression of Ovarian Cancer Cells.OncoTargets and therapy · 2020Article
- MiR-421 Is Overexpressed and Promotes Cell Proliferation in Non-Small Cell Lung Cancer.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020Article
- MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3'UTR and predicts poor survival in non-small cell lung cancer.Cell death & disease · 2019Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are expressed aberrantly in various types of cancer, and negatively regulate the expression of target genes which may be useful in therapeutic strategies in several biological processes. In the present study, the expression levels and the effects of miRNA (miR)‑421 in breast cancer tissues and MCF‑7 and MDA‑MB‑231 cells were evaluated to elucidate therapeutic targets in breast cancer cells. The putative targets of miR‑421 were predicted by bioinformatics approaches, and the expression levels of miR‑421 were measured in MCF‑7 and MDA‑MB‑231 cells by reverse transcription‑quantitative polymerase chain reaction analysis following miR‑421 knockdown. The rates of cell proliferation, migration capacity, invasiveness and apoptosis were determined in miR‑421 inhibitor‑transfected MCF‑7 and MDA‑MB‑231 cells. The expression levels of target proteins regulated by miR‑421 in MCF‑7 and MDA‑MB‑231 cells were analyzed by western blot analysis. miR‑421 was increased significantly in breast cancer tissues and cells, and was regulated by miR‑421 antisense oligonucleotides. The knockdown of miR‑421 in MCF‑7 and MDA‑MB‑231 cells decreased cell proliferation, migration capacity and invasiveness, and promoted apoptosis compared with control groups. The expression of target protein programmed cell death 4 (PDCD4) were decreased in MCF‑7 and MDA‑MB‑231 cells transfected with miR‑421 inhibitors. These results suggested a correlation between miR‑421 and PDCD4, and physiological functions of breast cancer cells, suggesting that miR‑421 may be a potential strategy in the therapy of breast cancer.
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