Evidence map›Paper›PMID 30365105›Full record

ArticleMolecular medicine reports2018

Expression of claudin‑11 in a rat model of varicocele and its effects on the blood‑testis barrier.

Jiangang Pan, Zhirong Zhu, Gang Xu, Lili Niu, Lihang Yu, Zhengang Luo, Jiajun Yan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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  15. Sertoli Cell Alterations in Peripubertal Varicocelized Rats: Evidence of Primary Damage on Spermatogenesis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiangang PanDepartment of Urology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.
Zhirong ZhuDepartment of Urology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.
Gang XuDepartment of Urology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.
Lili NiuDepartment of Urology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.
Lihang YuDepartment of Urology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.
Zhengang LuoDepartment of Urology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.
Jiajun YanDepartment of Urology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.
Shaoxing People's Hospital · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicocele (VC) is an abnormal tortuosity and venous distension of the pampiniform plexus in the spermatic cord. VC is the most common surgically correctable cause of male infertility. The purpose of the present study was to investigate the effects of VC on the tight junctions and the blood‑testis barrier (BTB) of Sertoli cells in the bilateral testes of rats. A model of VC was established by left renal vein narrowing in Sprague‑Dawley rats; control rats underwent dissection of the vein without narrowing. The bilateral testes were harvested at 4, 6 and 8 weeks after the operation. The relative expression of claudin‑11 and transforming growth factor (TGF)‑β in the testis was determined by reverse transcription‑polymerase chain reaction analysis and immunohistochemistry (IHC). The expression level of claudin‑11 was prominently downregulated in the VC model group compared with the control group, while the level of TGF‑β in the testes was higher in the VC group. IHC examination demonstrated that VC led to destruction of the integrity of the BTB, and the degree of destruction increased with time. Furthermore, it was also observed that unilateral VC affected contralateral testicular function. In conclusion, the present study partially explained the molecular mechanisms underlying the pathogenesis of VC and provided grounds for further research into the treatment of male infertility.

Indexed as

Gene ExpressionAnimalsBiomarkersBlood-Testis BarrierClaudinsDisease Models, AnimalMaleRatsVaricoceleBiomarkersClaudinsCldn11 protein, rat

Identifiers

PMID30365105
PMCPMC6236223
OpenAlexW2898191792

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.