ArticleMolecular medicine reports2018
In vitro study of the effects of reprogramming neonatal rat fibroblasts transfected with TBX18 on spontaneous beating in neonatal rat cardiomyocytes.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
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- Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p.ESC heart failure · 2023Article
- Bioengineering the Cardiac Conduction System: Advances in Cellular, Gene, and Tissue Engineering for Heart Rhythm Regeneration.Frontiers in bioengineering and biotechnology · 2021Review
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Intracardiac injection of the growth‑promoting transcription factor of the sinoatrial node T‑box18 (TBX18) has been shown to reprogram cardiomyocytes into induced sinoatrial nodes that produce high‑frequency and neuroregulated ectopic beats. Fibroblasts, the most important non‑cardiomyocyte cell type in the heart, can affect the electrophysiological properties of cardiomyocytes by electrically coupling with them. The aim of the present study was to explore the reprogramming of cardiac fibroblasts (CFs) transfected with TBX18 in vitro and observe its effect on the pacing frequency of neonatal rat ventricular cardiomyocytes (NRVMs) in a co‑culture system. CFs transfected with TBX18 could be transformed into cardiac myofibroblasts that expressed high levels of hyperpolarization‑activated cyclic nucleotide‑gated cation channel 4 protein and low levels of connexin 43 (COX43) and COX45 protein. In addition, TBX18‑CFs could increase the beating rates of NRVMs and TBX18‑NRVMs in a co‑culture system. The results of the present study indicated that the TBX18 gene could induce CFs to undergo a transformation that promotes an increase of the beating rates of NRVMs and TBX18‑NRVMs.
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