ArticleInternational journal of molecular medicine2019
Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism.
Article in International journal of molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Beyond vitamin D: integrating nuclear receptor signaling networks in periodontal health and disease.Frontiers in physiology · 2026Review
- Induction of osteogenic differentiation of MSCs by GSK3β knockdown through GSK3β siRNAs transfection.PloS one · 2026Article
- Injectable hydrogel microsphere orchestrates immune regulation and bone regeneration via sustained release of calcitriol.Materials today. Bio · 2025Article
- Effect of light on ascorbic acid biosynthesis and bioinformatics analysis of related genes in Chinese chives.PloS one · 2024Article
- In Vitro Effects of Photobiomodulation with 660 Nm Laser and Vitamin D on Osteoblastic Differentiation of Human Periodontal Ligament Stem Cells.Galen medical journal · 2024Article
- Vitamin D Alleviates Cadmium-Induced Inhibition of Chicken Bone Marrow Stromal Cells' Osteogenic Differentiation In Vitro.Animals : an open access journal from MDPI · 2023Article
- Emerging Roles of YAP/TAZ in Tooth and Surrounding: from Development to Regeneration.Stem cell reviews and reports · 2023Review
- Autophagy as a potential mechanism underlying the biological effect of 1,25-Dihydroxyvitamin D3 on periodontitis: a narrative review.BMC oral health · 2023Review
- Effects of vitamin A in promoting proliferation and osteogenic differentiation of human periodontal ligament cells.In vitro cellular & developmental biology. Animal · 2023Article
- Brassinolide improves the tolerance ofFrontiers in plant science · 2022Article
- The Wheat GeneFrontiers in plant science · 2022Article
- Effect of vitamin DJournal of periodontal research · 2021Article
- Low Vitamin D Status Is Associated with Inflammation in Patients with Chronic Obstructive Pulmonary Disease.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Effect of 1,25-Dihydroxyvitamin D3 on Stem Cells from Human Apical Papilla: Adhesion, Spreading, Proliferation, and Osteogenic Differentiation.BioMed research international · 2021Article
- Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts.Stem cells international · 2021Review
- Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin.Stem cells international · 2021Article
- Burst, Short, and Sustained Vitamin DInternational journal of molecular sciences · 2020Article
- Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways.Frontiers in cell and developmental biology · 2020Review
- Effect of Vitamins D and E on the Proliferation, Viability, and Differentiation of Human Dental Pulp Stem Cells: An In Vitro Study.International journal of dentistry · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1α, 25‑dihydroxyvitamin D3 (1,25‑D3), an active vitamin D metabolite, is a well‑known regulator of osteogenic differentiation. However, how 1,25‑D3 regulates osteogenic differentiation in human periodontal ligament stem cells (hPDLSCs) remains to be fully elucidated. The present study aimed to clarify this issue through well‑controlled in vitro experiments. After hPDLSCs were treated with 1,25‑D3, immunofluorescence and western blotting were used to detect the expression of vitamin D receptor; Cell Counting Kit‑8 and western blotting were used to assay the cell proliferation ability. Alkaline phosphatase staining, Alizarin Red staining and western blotting were used to detect the osteogenic differentiation. It was found that treating hPDLSCs with 1,25‑D3: i) Inhibited cell proliferation; ii) promoted osteogenic differentiation; iii) upregulated the expression of transcriptional coactivator with PDZ‑binding motif (TAZ), an important downstream effector of Hippo signaling that has been demonstrated to be involved in the osteogenic differentiation of stem/progenitor cells; and iv) that co‑treatment of TAZ‑overexpressing hPDLSCs with 1,25‑D3 synergistically stimulated the expression of osteogenic markers. These results suggested that the induction of osteogenic differentiation promoted by 1,25‑D3 in hPDLSCs involves, at least in part, the action of TAZ.
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