Evidence map›Paper›PMID 30364928›Full record

ArticleBrain : a journal of neurology2018

TDP-43 mutations increase HNRNP A1-7B through gain of splicing function.

Prasanth Sivakumar, Francesca De Giorgio, Agnieszka M Ule, Jacob Neeves, Remya R Nair, Matthew Bentham, Nicol Birsa, Jack Humphrey, Vincent Plagnol, Abraham Acevedo-Arozena and 3 more

Open access · bronzeAbstract readLetterComment
PubMed Publisher
In one paragraph

Article in Brain : a journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Prasanth SivakumarDepartment of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
Francesca De GiorgioDepartment of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
Agnieszka M UleDepartment of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
Jacob NeevesDepartment of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
Remya R NairMammalian Genetics Unit, MRC Harwell Institute, Oxford, UK.
Matthew BenthamDepartment of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
Nicol BirsaDepartment of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
Jack HumphreyDepartment of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
Vincent PlagnolUniversity College London Genetics Institute, Gower Street, London, UK.
Abraham Acevedo-ArozenaUnidad de Investigación, Hospital Universitario de Canarias, Fundación Canaria de Investigación Sanitaria and Instituto de Tecnologías Biomédicas, La Laguna, Spain.
Thomas J CunninghamMammalian Genetics Unit, MRC Harwell Institute, Oxford, UK.
Elizabeth M C FisherDepartment of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
Pietro FrattaDepartment of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
University College London · GBNational Hospital for Neurology and Neurosurgery · GBMary Lyon Centre at MRC Harwell · GBHospital Universitario de Canarias · ES

Funding

Medical Research Council G0500288Medical Research Council G0801110Medical Research Council MC_EX_MR/N501931/1Medical Research Council MR/K018523/1Medical Research Council MR/L021056/1Medical Research Council MR/M008606/1Medical Research Council MR/R005184/1Motor Neurone Disease Association FISHER/OCT14/876-792Motor Neurone Disease Association FRATTA/JAN15/946-795
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyotrophic Lateral SclerosisHeterogeneous-Nuclear Ribonucleoprotein Group A-BAlternative SplicingDNA-Binding ProteinsHeterogeneous Nuclear Ribonucleoprotein A1HumansMutationRNA SplicingDNA-Binding ProteinsHeterogeneous Nuclear Ribonucleoprotein A1Heterogeneous-Nuclear Ribonucleoprotein Group A-BTARDBP protein, human

Identifiers

PMID30364928
OpenAlexW2898272851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.