ArticleOpen heart
Survival in patients with univentricular hearts: the impact of right versus left ventricular morphology.
Article in Open heart. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Late Total Cavopulmonary Connection in Adolescents and Adults: Narrative Review of Patient Selection and Outcomes.Journal of cardiovascular development and disease · 2026Review
- Multimodal Imaging from Fetal to Adult Life: A Comprehensive Approach to Hypoplastic Left Heart Syndrome (HLHS).Journal of cardiovascular development and disease · 2025Review
- The Effect of Cardiac Rehabilitation in Paediatric Fontan Circulation Patients: A Prospective Intervention Study.Medicina (Kaunas, Lithuania) · 2024Article
- Risk Factors for Adverse Events in the Fontan Population: Does Ventricular Morphology Play a Role?JACC. Advances · 2024Article
- Long-Term Survival After Single-Ventricle Palliation: A Swedish Nationwide Cohort Study.Journal of the American Heart Association · 2024Article
- Effect of health education based on information-motivation-behavioral skills model on patients with unilateral vestibular dysfunction.World journal of clinical cases · 2024Article
- Relationship Between Obesity and Global Longitudinal Strain in the Pediatric Single Ventricle Fontan Population Across Ventricular Morphologies.Journal of the American Heart Association · 2024Article
- Article
- Cell-based therapy to boost right ventricular function and cardiovascular performance in hypoplastic left heart syndrome: Current approaches and future directions.Seminars in perinatology · 2023Review
- Care Pattern for Fontan-Associated Liver Disease by Academic Pediatric Hepatologists in Canada.JPGN reports · 2022Article
- Long-Term Risk of Heart Failure-Related Death and Heart Transplant After Congenital Heart Surgery in Childhood (from the Pediatric Cardiac Care Consortium).The American journal of cardiology · 2022Article
- The pathophysiology and complications of Fontan circulation.Acta bio-medica : Atenei Parmensis · 2021Review
- Metabolic profiles identify circulating biomarkers associated with heart failure in young single ventricle patients.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Spectrum of Fontan-associated liver disease assessed by MRI and US in young adolescents.Abdominal radiology (New York) · 2021Article
- Imaging of complications following Fontan circulation in children - diagnosis and surveillance.Pediatric radiology · 2020Review
- Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study.American heart journal · 2020Article
- Right ventricular failure in congenital heart disease.Current opinion in pediatrics · 2019Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Patients with univentricular hearts (UVH) have high mortality despite modern treatment, and better methods to identify patients at highest risk are needed. We wanted to improve risk stratification in patients with UVH by focusing on the prognostic significance of single right versus single left ventricular morphology (SRV vs SLV). Methods: All 395 patients with UVH operated at our centre were prospectively included from 1972 to 2016 (195 SRV, 166 SLV, 34 mixed or indeterminate ventricular morphology). Diagnoses, UVH morphology, types of all operations and time and causes of death or heart transplantation (HTX) were recorded. The primary endpoint was death or HTX. Results: Among the 111 non-Fontan patients, 88 died (SRV 62 vs SLV 20; p<0.0001), 32 due to heart failure (SRV 23 vs SLV 5; p=0.0012). Twenty-five years of cumulative SRV versus SLV survival among the 284 Fontan patients (41 deaths/HTX) was 66.9% vs 87.9% (p=0.0027), partly explained by more deaths/HTX due to heart failure among patients with SRV (p=0.0006). Survival in patients with SRV with and without hypoplastic left heart syndrome (HLHS) was similar. SRV versus SLV was a strong predictor of death/HTX in multivariable proportional hazards analyses (RR 3.3, 95% CI 1.6 to 6.6). Conclusion: SRV versus SLV is a strong short-term and long-term predictor of survival among patients with UVH, mainly explained by higher rates of death/HTX due to heart failure in the SRV group. Our findings apply to patients with SRV both with and without HLHS.
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