Evidence map›Paper›PMID 30364521›Full record

ReviewTherapeutic advances in chronic disease2018

The association of physical function and physical activity with all-cause mortality and adverse clinical outcomes in nondialysis chronic kidney disease: a systematic review.

Heather J MacKinnon, Thomas J Wilkinson, Amy L Clarke, Douglas W Gould, Thomas F O'Sullivan, Soteris Xenophontos, Emma L Watson, Sally J Singh, Alice C Smith

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Therapeutic advances in chronic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 8 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 8 syntheses or guidelines pooled it, 146 citations in OpenAlex.

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  5. Physical function predicts mortality in patients with cancer: a systematic review and meta-analysis of observational studies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Heather J MacKinnonLeicester Kidney Lifestyle Team, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-3530-0471
Thomas J WilkinsonLeicester Kidney Lifestyle Team, Department of Infection, Immunity and Inflammation, University of Leicester, LE1 7RH Leicester, UK.
Amy L ClarkeLeicester Kidney Lifestyle Team, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Douglas W GouldLeicester Kidney Lifestyle Team, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Thomas F O'SullivanLeicester Kidney Lifestyle Team, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Soteris XenophontosLeicester Kidney Lifestyle Team, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Emma L WatsonLeicester Kidney Lifestyle Team, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Sally J SinghSchool of Sport, Exercise and Health Sciences, National Centre for Sport and Exercise Medicine, Loughborough University, Loughborough, UK.
Alice C SmithLeicester Kidney Lifestyle Team, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
University of Leicester · GBLoughborough University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePeople with nondialysis-dependent chronic kidney disease (CKD) and renal transplant recipients (RTRs) have compromised physical function and reduced physical activity (PA) levels. Whilst established in healthy older adults and other chronic diseases, this association remains underexplored in CKD. We aimed to review the existing research investigating poor physical function and PA with clinical outcome in nondialysis CKD. DATA SOURCES: Electronic databases (PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials) were searched until December 2017 for cohort studies reporting objective or subjective measures of PA and physical function and the associations with adverse clinical outcomes and all-cause mortality in patients with nondialysis CKD stages 1-5 and RTRs. The protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42016039060). REVIEW

methodsStudy quality was assessed using the Newcastle-Ottawa Scale and the Agency for Healthcare and Research Quality (AHRQ) standards.

resultsA total of 29 studies were included; 12 reporting on physical function and 17 on PA. Only eight studies were conducted with RTRs. The majority were classified as 'good' according to the AHRQ standards. Although not appropriate for meta-analysis due to variance in the outcome measures reported, a coherent pattern was seen with higher mortality rates or prevalence of adverse clinical events associated with lower PA and physical function levels, irrespective of the measurement tool used. Sources of bias included incomplete description of participant flow through the study and over reliance on self-report measures.

conclusionsIn nondialysis CKD, survival rates correlate with greater PA and physical function levels. Further trials are required to investigate causality and the effectiveness of physical function and PA interventions in improving outcomes. Future work should identify standard assessment protocols for PA and physical function.

Indexed as

kidney diseaseskidney transplantationmortalityphysical activityphysical function

Identifiers

PMID30364521
PMCPMC6196637
OpenAlexW2807139522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.