ArticleOpen heart
Non-cardiac chest pain: prognosis and secondary healthcare utilisation.
Article in Open heart. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Association of Isolated Coronary Microvascular Dysfunction With Mortality and Major Adverse Cardiac Events: A Systematic Review and Meta-Analysis of Aggregate Data.Journal of the American Heart Association · 2020Pooled it
- Long-term effects and predictors of change of internet-delivered cognitive behavioural therapy on cardiac anxiety in patients with non-cardiac chest pain: a randomized controlled trial.BMC psychiatry · 2024Trial
- The Effect of Internet-Delivered Cognitive Behavioral Therapy Versus Psychoeducation Only on Psychological Distress in Patients With Noncardiac Chest Pain: Randomized Controlled Trial.Journal of medical Internet research · 2022Trial
- Chest discomfort at night and risk of acute coronary syndrome: cross-sectional study of telephone conversations.Family practice · 2020Trial
- The impact of follow-up care for patients presenting with non-typical chest pain at the emergency department.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Article
- Sedentary Behavior and Cardiac Events and Mortality After Hospitalization for Acute Coronary Syndrome Symptoms: A Prospective Study.Circulation. Cardiovascular quality and outcomes · 2025Article
- Diagnosing acute coronary syndrome in telephone triage: does it matter who initially calls? A cross-sectional study.BMC primary care · 2025Article
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- Non-ischemic phenotypes of low-risk chest pain patients based on exercise stress echocardiography: a pilot study.Frontiers in cardiovascular medicine · 2025Article
- A Study on the Association Between Risk Factors and Psychosocial Factors of Non-Cardiac Chest Pain (NCCP) in Adults Aged 40 and Above Based on 2013-2018 US NHANES Data.Journal of pain research · 2025Article
- Analytical and Clinical Performance of High-Sensitivity Cardiac Troponin Point-of-Care Assays as an Aid in the Diagnosis of Myocardial Infarction: A Narrative Review.Emergency medicine international · 2025Review
- Incidence of primary care chest pain consultations during the COVID-19 pandemic: an interrupted time series analysis with routine care data.BMC primary care · 2024Article
- Prehospital management and outcomes of patients calling with chest pain as the main complaint.International journal of emergency medicine · 2024Article
- Validation and correlation of high-sensitive troponin I and troponin T in the emergency department.BMC cardiovascular disorders · 2024Article
- Diagnosis and Management of Noncardiac Chest Pain.Gastroenterology & hepatology · 2024Article
- Emergency Department Blood Pressure Treatment and Outcomes in Adults Presenting with Severe Hypertension.The western journal of emergency medicine · 2024Article
- Independent Predictors of Repeat Emergency Room Presentations: Insights from a Cohort of 1066 Consecutive Patients with Non-Cardiac Chest Pain Generating 4770 Repeat Presentations.Journal of clinical medicine · 2023Article
- Chest Pain Diagnosed as Acute Leukemia: Focus on Coagulation Abnormalities Rather Than White Blood Cell Count.Cureus · 2023Article
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Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Presentations of non-cardiac chest pain (NCCP) to the emergency department (ED) are increasing. More knowledge of prognosis and healthcare utilisation of patients with NCCP is necessary to optimise their management. Methods: This study is a prospective, observational, prevalence-based cohort study conducted from September 2015 to February 2016 with 1-year follow-up including all patients 18 years and older referred to the ED with chest pain. Discharge diagnoses, mortality, major adverse cardiac events (MACE), re-presentations to the ED, hospitalisations, cardiac interventions and outpatient monitoring were assessed. Results: More than 60% of the 1239 patients presenting with chest pain were discharged with NCCP. The all-cause 1-year mortality rate of patients with NCCP was 2.3% compared with 7.2% in patients with cardiac chest pain (CCP) (p<0.001) and the occurrence of MACE was 5.1% vs 8.3%, respectively (p=0.026). Previous history of coronary artery disease (CAD) in patients with NCCP was identified as a predictive factor for MACE (OR 4.30 (95% CI 1.24 to 14.89), p=0.021). Patients with NCCP had more non-invasive interventions than patients with CCP (proportion of 0.225 vs 0.165 per patient, p<0.001) and 13.7% of patients with NCCP re-presented at the ED within 1 year. Conclusion: The majority of patients referred to the ED with chest pain are discharged with NCCP. The prognosis of patients with NCCP is better than patients with CCP; however, they are at risk for MACE due to a history of CAD. Patients with NCCP moreover use a substantial amount of medical resources, stressing the importance of good triage to minimise unnecessary healthcare utilisation while still preventing MACE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.