Evidence map›Paper›PMID 30364441›Full record

ArticlePhotoacoustics2018

Impact of depth-dependent optical attenuation on wavelength selection for spectroscopic photoacoustic imaging.

Heechul Yoon, Geoffrey P Luke, Stanislav Y Emelianov

Abstract read
In one paragraph

Article in Photoacoustics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Heechul YoonSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, United States.
Geoffrey P LukeThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, United States.
Stanislav Y EmelianovSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, United States.

Funding

Functional, cellular, and molecular imaging and therapy monitoring using ultrasouR01CA158598 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI EMELIANOV, STANISLAV Y, ESTEVA, FRANCISCO J · 2012 to 2018
$2.8M
Molecular photothermal therapy of cancer using targeted metal nanoparticlesR01CA149740 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI EMELIANOV, STANISLAV Y · 2010 to 2014
$1.6M
NCI NIH HHS R01 CA149740NCI NIH HHS R01 CA158598
6 · The paper itself

Abstract

An optical wavelength selection method based on the stability of the absorption cross-section matrix to improve spectroscopic photoacoustic (sPA) imaging was recently introduced. However, spatially-varying chromophore concentrations cause the wavelength- and depth-dependent variations of the optical fluence, which degrades the accuracy of quantitative sPA imaging. This study introduces a depth-optimized method that determines an optimal wavelength set minimizing an inverse of the multiplication of absorption cross-section matrix and fluence matrix to minimize the errors in concentration estimation. This method assumes that the optical fluence distribution is known or can be attained otherwise. We used a Monte Carlo simulation of light propagation in tissue with various depths and concentrations of deoxy-/oxy-hemoglobin. We quantitatively compared the developed and current approaches, indicating that the choice of wavelength is critical and our approach is effective especially when quantifying deeper imaging targets.

Indexed as

Optimal wavelength selectionOxygen saturation estimationSpectral unmixingSpectroscopic photoacoustic imaging

Identifiers

PMID30364441
PMCPMC6197329

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.